Peritoneal fluid: Difference between revisions
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==Evaluation== | ==Evaluation== | ||
Look mainly for malignancy | Look mainly for malignancy. | ||
<gallery mode=packed heights=190> | <gallery mode=packed heights=190> | ||
File:Pap stain of adenocarcinoma in peritoneal fluid.png|Adenocarcinoma in peritoneal fluid with typical features, Pap stain. Vacuoles may be seen in both serous and mucinous adenocarcinomas. | File:Cytology of reactive mesothelium.jpg|'''Reactive mesothelium''', with typical features. Reactive mesothelium may be due to infection, trauma or cancer.<ref>Image by Mikael Häggström. MD.<br>Reference for findings and causes: {{cite web|url=https://www.labce.com/spg374393_reactive_mesothelial_cells.aspx|title=Reactive Mesothelial Cells|website=LabCE}}</ref> | ||
File:Cytology of normal mesothelium.jpg|Compare to '''normal mesothelium'''<ref>Image by Mikael Häggström<br>- {{cite web|title=Mesothelial cytopathology|website=Libre Pathology|accessdate=2022-10-18|url=https://librepathology.org/wiki/Mesothelial_cytopathology}}<br>- {{cite journal| author=Shidham VB, Layfield LJ| title=Introduction to the second edition of 'Diagnostic Cytopathology of Serous Fluids' as CytoJournal Monograph (CMAS) in Open Access. | journal=Cytojournal | year= 2021 | volume= 18 | issue= | pages= 30 | pmid=35126608 | doi=10.25259/CMAS_02_01_2021 | pmc=8813611}} | |||
File:Pap stain of adenocarcinoma in peritoneal fluid.png|'''Adenocarcinoma''' in peritoneal fluid with typical features, Pap stain. Vacuoles may be seen in both serous and mucinous adenocarcinomas. | |||
</gallery> | </gallery> | ||
When finding adenocarcinoma in pleural fluid in a female, and there is no other specimen, preferably perform immunostaining including PAX-8 and WT-1 to confirm a Müllerian tract origin. Also consider p53 to distinguish low-grade (wild-type staining) from high grade (aberrant staining) serous ovarian carcinoma. | When finding adenocarcinoma in pleural fluid in a female, and there is no other specimen, preferably perform immunostaining including PAX-8 and WT-1 to confirm a Müllerian tract origin. Also consider p53 to distinguish low-grade (wild-type staining) from high grade (aberrant staining) serous ovarian carcinoma. | ||
Revision as of 16:39, 18 October 2022
Author:
Mikael Häggström, M.D. [note 1]
Evaluation
Look mainly for malignancy.
-
Reactive mesothelium, with typical features. Reactive mesothelium may be due to infection, trauma or cancer.[1]
-
Compare to normal mesothelium<ref>Image by Mikael Häggström
- . Mesothelial cytopathology. Libre Pathology. Retrieved on 2022-10-18.
- Shidham VB, Layfield LJ (2021). "Introduction to the second edition of 'Diagnostic Cytopathology of Serous Fluids' as CytoJournal Monograph (CMAS) in Open Access. ". Cytojournal 18: 30. doi:. PMID 35126608. -
Adenocarcinoma in peritoneal fluid with typical features, Pap stain. Vacuoles may be seen in both serous and mucinous adenocarcinomas.
![Reactive mesothelium, with typical features. Reactive mesothelium may be due to infection, trauma or cancer.[1]](/index.php?title=Special:Upload&wpDestFile=Cytology_of_reactive_mesothelium.jpg){kind=link}
When finding adenocarcinoma in pleural fluid in a female, and there is no other specimen, preferably perform immunostaining including PAX-8 and WT-1 to confirm a Müllerian tract origin. Also consider p53 to distinguish low-grade (wild-type staining) from high grade (aberrant staining) serous ovarian carcinoma.
Reporting
Example report:
Peritoneal fluid:
Comment: Immunohistochemistry was performed, and showed tumor cells positive for PAX-8 and WT-1, and negative (null phenotype) for p53. These findings are consistent with a tumor of Müllerian (serous) origin. |
Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ Image by Mikael Häggström. MD.
Reference for findings and causes: . Reactive Mesothelial Cells. LabCE.
Image sources