Colitis: Difference between revisions
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{{Comprehensiveness}} | {{Comprehensiveness}} | ||
==Microscopic evaluation== | ==Microscopic evaluation== | ||
[[File:Histopathology of collagenous colitis.jpg|thumb|Also look for '''collagenous colitis''', with a thickened subepithelial collagen band that is typically more than 10 μm in thickness.<ref>{{cite web|url=https://www.pathologyoutlines.com/topic/coloncollagenous.html|website=Pathology Outlines|title=Collagenous colitis|author=Benjamin J. Van Treeck, M.D., Catherine E. Hagen, M.D.}} Topic Completed: 3 August 2020. Minor changes: 29 September 2020</ref>]] | [[File:Histopathology of collagenous colitis.jpg|thumb|200px|Also look for '''collagenous colitis''', with a thickened subepithelial collagen band that is typically more than 10 μm in thickness.<ref>{{cite web|url=https://www.pathologyoutlines.com/topic/coloncollagenous.html|website=Pathology Outlines|title=Collagenous colitis|author=Benjamin J. Van Treeck, M.D., Catherine E. Hagen, M.D.}} Topic Completed: 3 August 2020. Minor changes: 29 September 2020</ref>]] | ||
[[File:Histopathology of a crypt abscess.jpg|thumb|190px|Crypt abscess: neutrophils in the crypt lumen.]] | |||
*Look for signs of '''active''' (or acute) and/or '''chronic''' colitis: | *Look for signs of '''active''' (or acute) and/or '''chronic''' colitis: | ||
Revision as of 20:58, 7 November 2022
Author:
Mikael Häggström [note 1]
Comprehensiveness
On this resource, the following formatting is used for comprehensiveness:
- Minimal depth
- (Moderate depth)
- ((Comprehensive))
Microscopic evaluation
- Look for signs of active (or acute) and/or chronic colitis:
Signs of active (or acute) colitis:
- Neutrophilic cryptitis
- Neutrophilic crypt abscesses
- Ulceration or granulation tissue
- Ischemic changes (including superficial necrosis, hemorrhage, crypt shrinkage/dropout, fibrin thrombi)
Signs of chronic colitis:
- Abnormal crypt orientation
- Abnormal crypt branching
- Paneth cell or gastric metaplasia (only apllies in the left colon and rectum)
- Elevation of crypts relative to the muscularis mucosa
(Consider the clinical and/or endoscopic finding in the evaluation.)
Further workup of colitis
Distinguish:
- Distribution: Patchy versus diffuse
- Severity: Mild, moderate or severe
- Presence of crypt regeneration, granuloma, inflammatory pseudomembranes, parasites, viral inclusions or epithelial dysplasia.
Microscopy report
Example of a normal sample, when colitis was suspected in the referral:
| ( Optionally: Colonic/Rectal mucosa without significant histopathologic changes.) Negative for acute and chronic colitis. |
Example of findings of both active and chronic colitis:
| (Ascending, transverse, descending, and sigmoid colon, biopsies:) Mild chronic active colitis, with associated cryptitis and crypt abscesses. (Negative for ulceration, granulomata and dysplasia.) |
Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ Benjamin J. Van Treeck, M.D., Catherine E. Hagen, M.D.. Collagenous colitis. Pathology Outlines. Topic Completed: 3 August 2020. Minor changes: 29 September 2020
Image sources