Colitis: Difference between revisions
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===Further workup of colitis=== | ===Further workup of colitis=== | ||
Distinguish: | Distinguish: | ||
*'''Severity''': Mild, moderate or severe | *'''Severity''': Mild, moderate or severe | ||
*Presence of '''crypt regeneration''', '''granuloma''', inflammatory '''pseudomembranes''', '''parasites''', '''viral inclusions''' or '''epithelial dysplasia'''. | *Presence of '''crypt regeneration''', '''granuloma''', inflammatory '''pseudomembranes''', '''parasites''', '''viral inclusions''' or '''epithelial dysplasia'''. | ||
*{{Moderate-begin}}Distribution: '''Patchy''' versus '''diffuse'''{{Moderate-end}} | |||
===Microscopy report=== | ===Microscopy report=== | ||
Revision as of 10:44, 3 October 2023
Author:
Mikael Häggström [note 1]
Comprehensiveness
On this resource, the following formatting is used for comprehensiveness:
- Minimal depth
- (Moderate depth)
- ((Comprehensive))
Microscopic evaluation
- Look for signs of active (or acute) and/or chronic colitis:
Signs of active (or acute) colitis:
- Neutrophilic cryptitis
- Neutrophilic crypt abscesses
- Ulceration or granulation tissue
- Ischemic changes (including superficial necrosis, hemorrhage, crypt shrinkage/dropout, fibrin thrombi)
Signs of chronic colitis:
- Abnormal crypt orientation
- Abnormal crypt branching
- Paneth cell or gastric metaplasia (only apllies in the left colon and rectum)
- Elevation of crypts relative to the muscularis mucosa
(Consider the clinical and/or endoscopic findings in the evaluation.)
Further workup of colitis
Distinguish:
- Severity: Mild, moderate or severe
- Presence of crypt regeneration, granuloma, inflammatory pseudomembranes, parasites, viral inclusions or epithelial dysplasia.
- (Distribution: Patchy versus diffuse)
Microscopy report
Example of a normal sample, when colitis was suspected in the referral:
| ( Optionally: Colonic/Rectal mucosa without significant histopathologic changes.) Negative for acute and chronic colitis. |
Example of findings of both active and chronic colitis:
| (Ascending, transverse, descending, and sigmoid colon, biopsies:) Mild chronic active colitis(, with associated cryptitis and crypt abscesses. Negative for ulceration, granulomata and dysplasia.) |
Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ Benjamin J. Van Treeck, M.D., Catherine E. Hagen, M.D.. Collagenous colitis. Pathology Outlines. Topic Completed: 3 August 2020. Minor changes: 29 September 2020
Image sources