Dermatitis: Difference between revisions

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===Non vesicullobullous, non-pustular lesions without epidermal changes~~, lymphocytic~~ infiltrate===

===Non vesicullobullous, non-pustular lesions without epidermal changes===

====Lymphocytic infiltrate====

{|class="wikitable"

! Main conditions<ref name="Alsaad2005"/> !! Characteristics !! Image

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| A lesion with superficial lymphocytic infiltrate without additional histopathologic characteristics can be due to for example drug reactions and insect bites.<ref name="Alsaad2005"/>

|}

====Lymphoeosinophilic infiltrate====

{|class="wikitable"

! Main conditions<ref name="Alsaad2005"/> !! Characteristics !! Image

|-

! Urticaria, lymphocyte predominant

| Perivascular location. Mast cells are relatively sparse, potentially demonstrated with special stains, preferably tryptase stain. Extravasated erythrocytes are present in about 50% of the cases. No vasculitis.<ref name="BarzilaiSagi2017"/>

| [[File:Micrograph of urticaria.jpg|190px]] Dermal edema (solid arrows) and a sparse superficial predominantly perivascular and interstitial infiltrate of lymphocytes and eosinophils (dashed arrow)

|-

! Prevesicular stage of bullous pemphigoid

| Image at right shows influx of inflammatory cells including eosinophils and neutrophils in the dermis (solid arrow) and blister cavity (dashed arrows), and deposition of fibrin (asterisks).<ref>{{cite journal|last1=Giang|first1=Jenny|last2=Seelen|first2=Marc A. J.|last3=van Doorn|first3=Martijn B. A.|last4=Rissmann|first4=Robert|last5=Prens|first5=Errol P.|last6=Damman|first6=Jeffrey|title=Complement Activation in Inflammatory Skin Diseases|journal=Frontiers in Immunology|volume=9|year=2018|issn=1664-3224|doi=10.3389/fimmu.2018.00639}}</ref> However, the diagnosis of bullous pemphigoid consist of at least 2 positive results out of 3 criteria:<ref>{{cite journal | vauthors = Meijer JM, Diercks GF, de Lang EW, Pas HH, Jonkman MF | title = Assessment of diagnostic strategy for early recognition of bullous and nonbullous variants of pemphigoid. | journal = JAMA Dermatol | volume = 155 | issue = 2 | pages = 158–165 | doi = 10.1001/jamadermatol.2018.4390 | pmid = 30624575 | pmc = 6439538 | date = December 2018 }}</ref>

*Pruritus and/or predominant cutaneous blisters

*Linear IgG and/or C3c deposits (in an n- serrated pattern) by direct [[immunofluorescence]] microscopy (DIF)

*Positive epidermal side staining by [[indirect immunofluorescence]] microscopy on human salt-split skin (IIF SSS) on a serum sample.

| [[File:Micrograph of infiltrate in bullous pemphigoid.jpg|thumb|

|-

! Not otherwise specified

| A lesion with superficial lymphocytic infiltrate without additional histopathologic characteristics can be due to for example drug reactions and insect bites.<ref name="Alsaad2005"/>

@@ Line 44: / Line 44: @@
 |}
-===Non vesicullobullous, non-pustular lesions without epidermal changes, lymphocytic infiltrate===
+===Non vesicullobullous, non-pustular lesions without epidermal changes===
+====Lymphocytic infiltrate====
 {|class="wikitable"
 ! Main conditions<ref name="Alsaad2005"/> !! Characteristics !! Image
@@ Line 75: / Line 76: @@
 | A lesion with superficial lymphocytic infiltrate without additional histopathologic characteristics can be due to for example drug reactions and insect bites.<ref name="Alsaad2005"/>
 |}
+====Lymphoeosinophilic infiltrate====
+{|class="wikitable"
+! Main conditions<ref name="Alsaad2005"/> !! Characteristics !! Image
+|-
+! Urticaria, lymphocyte predominant
+| Perivascular location. Mast cells are relatively sparse, potentially demonstrated with special stains, preferably tryptase stain. Extravasated erythrocytes are present in about 50% of the cases. No vasculitis.<ref name="BarzilaiSagi2017"/>
+| [[File:Micrograph of urticaria.jpg|190px]] Dermal edema (solid arrows) and a sparse superficial predominantly perivascular and interstitial infiltrate of lymphocytes and eosinophils (dashed arrow)
+|-
+! Prevesicular stage of bullous pemphigoid
+| Image at right shows influx of inflammatory cells including eosinophils and neutrophils in the dermis (solid arrow) and blister cavity (dashed arrows), and deposition of fibrin (asterisks).<ref>{{cite journal|last1=Giang|first1=Jenny|last2=Seelen|first2=Marc A. J.|last3=van Doorn|first3=Martijn B. A.|last4=Rissmann|first4=Robert|last5=Prens|first5=Errol P.|last6=Damman|first6=Jeffrey|title=Complement Activation in Inflammatory Skin Diseases|journal=Frontiers in Immunology|volume=9|year=2018|issn=1664-3224|doi=10.3389/fimmu.2018.00639}}</ref> However, the diagnosis of bullous pemphigoid consist of at least 2 positive results out of 3 criteria:<ref>{{cite journal | vauthors = Meijer JM, Diercks GF, de Lang EW, Pas HH, Jonkman MF | title = Assessment of diagnostic strategy for early recognition of bullous and nonbullous variants of pemphigoid. | journal = JAMA Dermatol | volume = 155 | issue = 2 | pages = 158–165 | doi = 10.1001/jamadermatol.2018.4390 | pmid = 30624575 | pmc = 6439538 | date = December 2018 }}</ref>
+*Pruritus and/or predominant cutaneous blisters
+*Linear IgG and/or C3c deposits (in an n- serrated pattern) by direct [[immunofluorescence]] microscopy (DIF)
+*Positive epidermal side staining by [[indirect immunofluorescence]] microscopy on human salt-split skin (IIF SSS) on a serum sample.
+| [[File:Micrograph of infiltrate in bullous pemphigoid.jpg|thumb|
+|-
+! Not otherwise specified
+| A lesion with superficial lymphocytic infiltrate without additional histopathologic characteristics can be due to for example drug reactions and insect bites.<ref name="Alsaad2005"/>
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Dermatitis: Difference between revisions

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