Template:Immunohistochemistry evaluation of invasive breast cancer: Difference between revisions
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! rowspan="2" | Average HER2 copy number per cell | ! rowspan="2" | Average HER2 copy number per cell | ||
! ≥4.0 | ! ≥4.0 | ||
| HER2 positive | | style="background:Pink" | HER2 positive | ||
| Additional work-up required<ref name=HER2fish group=note>If additional work-up is required by FISH study, see source article for detailed algorithms:<br>{{cite journal| author=Wolff AC, Hammond MEH, Allison KH, Harvey BE, Mangu PB, Bartlett JMS | display-authors=etal| title=Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer: American Society of Clinical Oncology/College of American Pathologists Clinical Practice Guideline Focused Update. | journal=J Clin Oncol | year= 2018 | volume= 36 | issue= 20 | pages= 2105-2122 | pmid=29846122 | doi=10.1200/JCO.2018.77.8738 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29846122 }}</ref> | | style="background:LemonChiffon" | Additional work-up required<ref name=HER2fish group=note>If additional work-up is required by FISH study, see source article for detailed algorithms:<br>{{cite journal| author=Wolff AC, Hammond MEH, Allison KH, Harvey BE, Mangu PB, Bartlett JMS | display-authors=etal| title=Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer: American Society of Clinical Oncology/College of American Pathologists Clinical Practice Guideline Focused Update. | journal=J Clin Oncol | year= 2018 | volume= 36 | issue= 20 | pages= 2105-2122 | pmid=29846122 | doi=10.1200/JCO.2018.77.8738 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29846122 }}</ref> | ||
|- | |- | ||
! <4.0 | ! <4.0 | ||
| Additional work-up required<ref name=HER2fish group=note/> | | style="background:LemonChiffon" | Additional work-up required<ref name=HER2fish group=note/> | ||
| HER2 negative | | style="background:LightGreen" | HER2 negative | ||
|} | |} | ||
If the initial HER2 result is negative for a needle biopsy of a primary breast cancer, a new HER2 test may be performed on the subsequent breast excision.<ref name=HER2fish group=note/> | If the initial HER2 result is negative for a needle biopsy of a primary breast cancer, a new HER2 test may be performed on the subsequent breast excision.<ref name=HER2fish group=note/> | ||