Template:IHC of MMR

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(Perform immunohistochemistry for MLH-1, PMS-2, MSH-2 and MSH-6.) They are scored as:[1]

  • 0% nuclear expression in tumor cell nuclei: Loss of expression (expression seen in stromal cells in image)
    0% nuclear expression in tumor cell nuclei: Loss of expression (expression seen in stromal cells in image)
  • More than 0% but less than 10%: Indeterminate expression
    More than 0% but less than 10%: Indeterminate expression
  • 10% or more: Retained expression
    10% or more: Retained expression

Notes


Main page

References

  1. ↑ These cutoffs are used for both colorectal and endometrial cancers:
    - Sarode, Venetia R.; Robinson, Linda (2019). "Screening for Lynch Syndrome by Immunohistochemistry of Mismatch Repair Proteins: Significance of Indeterminate Result and Correlation With Mutational Studies ". Archives of Pathology & Laboratory Medicine 143 (10): 1225–1233. doi:10.5858/arpa.2018-0201-OA. ISSN 0003-9985. 
    - Sarode VR, Robinson L (2019). "Screening for Lynch Syndrome by Immunohistochemistry of Mismatch Repair Proteins: Significance of Indeterminate Result and Correlation With Mutational Studies. ". Arch Pathol Lab Med 143 (10): 1225-1233. doi:10.5858/arpa.2018-0201-OA. PMID 30917047. Archived from the original. . 
    - Lee JHS, Li JJX, Chow C, Chan RCK, Kwan JSH, Lau TS (2021). "Long-Term Survival and Clinicopathological Implications of DNA Mismatch Repair Status in Endometrioid Endometrial Cancers in Hong Kong Chinese Women. ". Biomedicines 9 (10). doi:10.3390/biomedicines9101385. PMID 34680502. PMC: 8533409. Archived from the original. . 

Image sources


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