Template:Esophagitis

Esophagitis

File:Histopathology of acute and chronic inflammation of the gastro-esophageal junction, annotated.jpg

GE junction with chronic esophagitis, including plasma cells (black arrow), an acute inflammation with neutrophils (white arrow), as well as basal layer hyperplasia (yellow double-headed arrow).

Look for signs of (reflux) esophagitis, mainly:

• Inflammatory cells, especially when intra-epithelial. Neutrophils confer a diagnosis of acute inflammation, while plasma cells, eosinophils and excess T cells confer a diagnosis of chronic inflammation.
• Basal cell hyperplasia exceeding 15 - 20% of the epithelial thickness.
• Stromal papillae reaching upper third of the epithelium.
• Ballooned squamous cells

• An intra-epithelial eosinophil (characterized by its bilobed nucleus despite scant visible eosinophilic cytoplasm)
  An intra-epithelial eosinophil (characterized by its bilobed nucleus despite scant visible eosinophilic cytoplasm)