Bone marrow

Author: Mikael Häggström

Bone marrow aspirate showing normal "trilineage hematopoiesis":
- Myelomonocytic cells: an eosinophil myelocyte marked
- Erythroid cells: an orthochromatic erythroblast marked
- Megakaryocytic cells.

Autopsy

Microscopic evaluation

• Confirm trilineage hematopoiesis (see image).
• Look for apparent cellular atypia or decrease of cellular diversity.

Report

Example in a normal case:

Bone marrow from rib (or other location if applicable): Trilineage hematopoiesis. There is no evidence of malignancy.

Bone marrow biopsy

Evaluate the following:

• Adequacy: There should preferably be 5 intertrabecular spaces.
• Cellularity: In patients 20-80 years, the percentage should be about 100 minus age, such as 40% in a 60 year old patient.
• Thrombopoiesis: There are normally about 3 megakaryocytes per 40x field.
• Myeloid/erythroid ratio, normally 3-4 myeloid cells per erythroid cell.
• Look for any granuloma or cancer metastasis

Main page

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