https://patholines.org/index.php?title=Atypical_ductal_hyperplasia&feed=atom&action=history
Atypical ductal hyperplasia - Revision history
2024-03-29T09:01:48Z
Revision history for this page on the wiki
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https://patholines.org/index.php?title=Atypical_ductal_hyperplasia&diff=6519&oldid=prev
Mikael Häggström: <noinclude>
2022-12-02T23:45:28Z
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<td colspan="2" style="background-color: #fff; color: #222; text-align: center;">Revision as of 23:45, 2 December 2022</td>
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<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>{{Top</div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><noinclude></ins>{{Top</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|author1=[[User:Mikael Häggström|Mikael Häggström]]</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|author1=[[User:Mikael Häggström|Mikael Häggström]]</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|author2=</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|author2=</div></td></tr>
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<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Gross examination==</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Gross examination==</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>As per:</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>As per:</div></td></tr>
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<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[File:Histopathology of usual ductal hyperplasia.jpg|thumb|200px|'''[[Usual ductal hyperplasia]]''']]</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[File:Histopathology of usual ductal hyperplasia.jpg|thumb|200px|'''[[Usual ductal hyperplasia]]''']]</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Usual ductal hyperplasia versus atypical ductal hyperplasia}}</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Usual ductal hyperplasia versus atypical ductal hyperplasia}}</div></td></tr>
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Mikael Häggström
https://patholines.org/index.php?title=Atypical_ductal_hyperplasia&diff=5365&oldid=prev
Mikael Häggström: +Image
2022-04-28T22:29:16Z
<p>+Image</p>
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<td colspan="2" style="background-color: #fff; color: #222; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #222; text-align: center;">Revision as of 22:29, 28 April 2022</td>
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<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>;Usual ductal hyperplasia (UDH)</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>;Usual ductal hyperplasia (UDH)</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[File:Histopathology of usual ductal hyperplasia.jpg|thumb|200px|'''[[Usual ductal hyperplasia]]''']]</ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Usual ductal hyperplasia versus atypical ductal hyperplasia}}</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Usual ductal hyperplasia versus atypical ductal hyperplasia}}</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Bottom}}</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Bottom}}</div></td></tr>
</table>
Mikael Häggström
https://patholines.org/index.php?title=Atypical_ductal_hyperplasia&diff=5360&oldid=prev
Mikael Häggström: /* Microscopic evaluation */ Templated
2022-04-28T22:14:32Z
<p><span dir="auto"><span class="autocomment">Microscopic evaluation: </span> Templated</span></p>
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<td colspan="2" style="background-color: #fff; color: #222; text-align: center;">Revision as of 22:14, 28 April 2022</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l21" >Line 21:</td>
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<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*The proliferation completely involves the terminal ductal lobular unit(s), to a limited extent.</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*The proliferation completely involves the terminal ductal lobular unit(s), to a limited extent.</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Also, ADH tends to have rounded lacunae between cells, in contrast to more crescent-shaped (compressed) lucunae in DCIS.</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Also, ADH tends to have rounded lacunae between cells, in contrast to more crescent-shaped (compressed) lucunae in DCIS.</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">;Usual ductal hyperplasia (UDH)</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">{{Usual ductal hyperplasia versus atypical ductal hyperplasia}}</ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Bottom}}</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Bottom}}</div></td></tr>
</table>
Mikael Häggström
https://patholines.org/index.php?title=Atypical_ductal_hyperplasia&diff=3836&oldid=prev
Mikael Häggström: /* Microscopic evaluation */ size
2021-09-15T18:45:47Z
<p><span dir="auto"><span class="autocomment">Microscopic evaluation: </span> size</span></p>
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<td colspan="2" style="background-color: #fff; color: #222; text-align: center;">Revision as of 18:45, 15 September 2021</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l10" >Line 10:</td>
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<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Microscopic evaluation==</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Microscopic evaluation==</div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>[[File:Atypical ductal hyperplasia with immunotyping.jpg|thumb|<del class="diffchange diffchange-inline">300px</del>|Histological appearance of atypical ductal hyperplasia (ADH) and immunohistochemical phenotype:<ref>{{cite journal|last1=Rageth|first1=Christoph J.|last2=Rubenov|first2=Ravit|last3=Bronz|first3=Cristian|last4=Dietrich|first4=Daniel|last5=Tausch|first5=Christoph|last6=Rodewald|first6=Ann-Katrin|last7=Varga|first7=Zsuzsanna|title=Atypical ductal hyperplasia and the risk of underestimation: tissue sampling method, multifocality, and associated calcification significantly influence the diagnostic upgrade rate based on subsequent surgical specimens|journal=Breast Cancer|volume=26|issue=4|year=2018|pages=452–458|issn=1340-6868|doi=10.1007/s12282-018-00943-2}} This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/)</ref> <br>- A - One focus (< 2 mm) of two architecturally disarranged cross sections of tubuli showing a monotonous intraductal proliferation with secondary intraluminal architecture.<br>- B - One area of an ADH with associated intraluminal calcifications.<br>- C - Higher magnification of ADH shows low-grade nuclear atypia and monotonous cell proliferation along with secondary intraluminal architecture.<br>- D - Strong and uniform expression of estrogen receptors (ER). ER immunohistochemistry. <br>- E - Lack of basal cytokeratins (CK5/6). CK5/6 immunohistochemistry.]]</div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>[[File:Atypical ductal hyperplasia with immunotyping.jpg|thumb|<ins class="diffchange diffchange-inline">400px</ins>|Histological appearance of atypical ductal hyperplasia (ADH) and immunohistochemical phenotype:<ref>{{cite journal|last1=Rageth|first1=Christoph J.|last2=Rubenov|first2=Ravit|last3=Bronz|first3=Cristian|last4=Dietrich|first4=Daniel|last5=Tausch|first5=Christoph|last6=Rodewald|first6=Ann-Katrin|last7=Varga|first7=Zsuzsanna|title=Atypical ductal hyperplasia and the risk of underestimation: tissue sampling method, multifocality, and associated calcification significantly influence the diagnostic upgrade rate based on subsequent surgical specimens|journal=Breast Cancer|volume=26|issue=4|year=2018|pages=452–458|issn=1340-6868|doi=10.1007/s12282-018-00943-2}} This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/)</ref> <br>- A - One focus (< 2 mm) of two architecturally disarranged cross sections of tubuli showing a monotonous intraductal proliferation with secondary intraluminal architecture.<br>- B - One area of an ADH with associated intraluminal calcifications.<br>- C - Higher magnification of ADH shows low-grade nuclear atypia and monotonous cell proliferation along with secondary intraluminal architecture.<br>- D - Strong and uniform expression of estrogen receptors (ER). ER immunohistochemistry. <br>- E - Lack of basal cytokeratins (CK5/6). CK5/6 immunohistochemistry.]]</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Atypical ductal hyperplasia shows epithelial proliferations which are not qualitatively or quantitatively abnormal enough to be classified as ductal carcinoma in situ.<ref name=Statpearls-atypical>{{cite web|url=https://www.ncbi.nlm.nih.gov/books/NBK470258/|title=Atypical Breast Hyperplasia|author=David J. Myers; Andrew L. Walls.|website=StatPearls, National Center for Biotechnology Information}} Last Update: February 15, 2019.</ref></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Atypical ductal hyperplasia shows epithelial proliferations which are not qualitatively or quantitatively abnormal enough to be classified as ductal carcinoma in situ.<ref name=Statpearls-atypical>{{cite web|url=https://www.ncbi.nlm.nih.gov/books/NBK470258/|title=Atypical Breast Hyperplasia|author=David J. Myers; Andrew L. Walls.|website=StatPearls, National Center for Biotechnology Information}} Last Update: February 15, 2019.</ref></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
</table>
Mikael Häggström
https://patholines.org/index.php?title=Atypical_ductal_hyperplasia&diff=3702&oldid=prev
Mikael Häggström: /* Microscopic evaluation */ Format
2021-08-02T23:31:48Z
<p><span dir="auto"><span class="autocomment">Microscopic evaluation: </span> Format</span></p>
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<td colspan="2" style="background-color: #fff; color: #222; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #222; text-align: center;">Revision as of 23:31, 2 August 2021</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l10" >Line 10:</td>
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<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Microscopic evaluation==</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Microscopic evaluation==</div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>[[File:Atypical ductal hyperplasia with immunotyping.jpg|thumb|300px|Histological appearance of atypical ductal hyperplasia (ADH) and immunohistochemical phenotype:<ref>{{cite journal|last1=Rageth|first1=Christoph J.|last2=Rubenov|first2=Ravit|last3=Bronz|first3=Cristian|last4=Dietrich|first4=Daniel|last5=Tausch|first5=Christoph|last6=Rodewald|first6=Ann-Katrin|last7=Varga|first7=Zsuzsanna|title=Atypical ductal hyperplasia and the risk of underestimation: tissue sampling method, multifocality, and associated calcification significantly influence the diagnostic upgrade rate based on subsequent surgical specimens|journal=Breast Cancer|volume=26|issue=4|year=2018|pages=452–458|issn=1340-6868|doi=10.1007/s12282-018-00943-2}} This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/)</ref> <br>- A - One focus (< 2 mm) of two architecturally disarranged cross sections of tubuli showing a monotonous intraductal proliferation with secondary intraluminal architecture<del class="diffchange diffchange-inline">. Hematoxylin and Eosin stain</del>. <br>- B - One area of an ADH with associated calcifications <del class="diffchange diffchange-inline">intraluminal. Hematoxylin and Eosin stain</del>. <br>- C - Higher magnification of ADH shows low-grade nuclear atypia and monotonous cell proliferation along with secondary intraluminal architecture<del class="diffchange diffchange-inline">. Hematoxylin and Eosin stain</del>. <br>- D - Strong and uniform expression of estrogen receptors (ER). ER immunohistochemistry. <br>- E - Lack of basal cytokeratins (CK5/6). CK5/6 immunohistochemistry.]]</div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>[[File:Atypical ductal hyperplasia with immunotyping.jpg|thumb|300px|Histological appearance of atypical ductal hyperplasia (ADH) and immunohistochemical phenotype:<ref>{{cite journal|last1=Rageth|first1=Christoph J.|last2=Rubenov|first2=Ravit|last3=Bronz|first3=Cristian|last4=Dietrich|first4=Daniel|last5=Tausch|first5=Christoph|last6=Rodewald|first6=Ann-Katrin|last7=Varga|first7=Zsuzsanna|title=Atypical ductal hyperplasia and the risk of underestimation: tissue sampling method, multifocality, and associated calcification significantly influence the diagnostic upgrade rate based on subsequent surgical specimens|journal=Breast Cancer|volume=26|issue=4|year=2018|pages=452–458|issn=1340-6868|doi=10.1007/s12282-018-00943-2}} This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/)</ref> <br>- A - One focus (< 2 mm) of two architecturally disarranged cross sections of tubuli showing a monotonous intraductal proliferation with secondary intraluminal architecture.<br>- B - One area of an ADH with associated <ins class="diffchange diffchange-inline">intraluminal </ins>calcifications.<br>- C - Higher magnification of ADH shows low-grade nuclear atypia and monotonous cell proliferation along with secondary intraluminal architecture.<br>- D - Strong and uniform expression of estrogen receptors (ER). ER immunohistochemistry. <br>- E - Lack of basal cytokeratins (CK5/6). CK5/6 immunohistochemistry.]]</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Atypical ductal hyperplasia shows epithelial proliferations which are not qualitatively or quantitatively abnormal enough to be classified as ductal carcinoma in situ.<ref name=Statpearls-atypical>{{cite web|url=https://www.ncbi.nlm.nih.gov/books/NBK470258/|title=Atypical Breast Hyperplasia|author=David J. Myers; Andrew L. Walls.|website=StatPearls, National Center for Biotechnology Information}} Last Update: February 15, 2019.</ref></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Atypical ductal hyperplasia shows epithelial proliferations which are not qualitatively or quantitatively abnormal enough to be classified as ductal carcinoma in situ.<ref name=Statpearls-atypical>{{cite web|url=https://www.ncbi.nlm.nih.gov/books/NBK470258/|title=Atypical Breast Hyperplasia|author=David J. Myers; Andrew L. Walls.|website=StatPearls, National Center for Biotechnology Information}} Last Update: February 15, 2019.</ref></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
</table>
Mikael Häggström
https://patholines.org/index.php?title=Atypical_ductal_hyperplasia&diff=3621&oldid=prev
Mikael Häggström: /* Differential diagnoses */ Other
2021-07-13T16:25:46Z
<p><span dir="auto"><span class="autocomment">Differential diagnoses: </span> Other</span></p>
<table class="diff diff-contentalign-left" data-mw="interface">
<col class="diff-marker" />
<col class="diff-content" />
<col class="diff-marker" />
<col class="diff-content" />
<tr class="diff-title" lang="en">
<td colspan="2" style="background-color: #fff; color: #222; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #222; text-align: center;">Revision as of 16:25, 13 July 2021</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l20" >Line 20:</td>
<td colspan="2" class="diff-lineno">Line 20:</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*The atypical epithelial proliferation is admixed with a second population of proliferative cells without atypia.</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*The atypical epithelial proliferation is admixed with a second population of proliferative cells without atypia.</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*The proliferation completely involves the terminal ductal lobular unit(s), to a limited extent.</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*The proliferation completely involves the terminal ductal lobular unit(s), to a limited extent.</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Also, ADH tends to have rounded lacunae between cells, in contrast to more crescent-shaped (compressed) lucunae in DCIS.</ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Bottom}}</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Bottom}}</div></td></tr>
</table>
Mikael Häggström
https://patholines.org/index.php?title=Atypical_ductal_hyperplasia&diff=393&oldid=prev
Mikael Häggström: /* Microscopic evaluation */ Formatting
2019-10-02T12:01:11Z
<p><span dir="auto"><span class="autocomment">Microscopic evaluation: </span> Formatting</span></p>
<table class="diff diff-contentalign-left" data-mw="interface">
<col class="diff-marker" />
<col class="diff-content" />
<col class="diff-marker" />
<col class="diff-content" />
<tr class="diff-title" lang="en">
<td colspan="2" style="background-color: #fff; color: #222; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #222; text-align: center;">Revision as of 12:01, 2 October 2019</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l13" >Line 13:</td>
<td colspan="2" class="diff-lineno">Line 13:</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Atypical ductal hyperplasia shows epithelial proliferations which are not qualitatively or quantitatively abnormal enough to be classified as ductal carcinoma in situ.<ref name=Statpearls-atypical>{{cite web|url=https://www.ncbi.nlm.nih.gov/books/NBK470258/|title=Atypical Breast Hyperplasia|author=David J. Myers; Andrew L. Walls.|website=StatPearls, National Center for Biotechnology Information}} Last Update: February 15, 2019.</ref></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Atypical ductal hyperplasia shows epithelial proliferations which are not qualitatively or quantitatively abnormal enough to be classified as ductal carcinoma in situ.<ref name=Statpearls-atypical>{{cite web|url=https://www.ncbi.nlm.nih.gov/books/NBK470258/|title=Atypical Breast Hyperplasia|author=David J. Myers; Andrew L. Walls.|website=StatPearls, National Center for Biotechnology Information}} Last Update: February 15, 2019.</ref></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">===Differential diagnoses===</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">;[[Ductal carcinoma in situ]]</ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>There is no single definite cutoff that separates atypical ductal hyperplasia from [[ductal carcinoma in situ]], but the following are important distinctive features of atypical ductal hyperplasia, with suggested cutoffs:<ref name="TozbikianBrogi2016">{{cite journal|last1=Tozbikian|first1=Gary|last2=Brogi|first2=Edi|last3=Vallejo|first3=Christina E.|last4=Giri|first4=Dilip|last5=Murray|first5=Melissa|last6=Catalano|first6=Jeffrey|last7=Olcese|first7=Cristina|last8=Van Zee|first8=Kimberly J.|last9=Wen|first9=Hannah Yong|title=Atypical Ductal Hyperplasia Bordering on Ductal Carcinoma In Situ|journal=International Journal of Surgical Pathology|volume=25|issue=2|year=2016|pages=100–107|issn=1066-8969|doi=10.1177/1066896916662154}}</ref></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>There is no single definite cutoff that separates atypical ductal hyperplasia from [[ductal carcinoma in situ]], but the following are important distinctive features of atypical ductal hyperplasia, with suggested cutoffs:<ref name="TozbikianBrogi2016">{{cite journal|last1=Tozbikian|first1=Gary|last2=Brogi|first2=Edi|last3=Vallejo|first3=Christina E.|last4=Giri|first4=Dilip|last5=Murray|first5=Melissa|last6=Catalano|first6=Jeffrey|last7=Olcese|first7=Cristina|last8=Van Zee|first8=Kimberly J.|last9=Wen|first9=Hannah Yong|title=Atypical Ductal Hyperplasia Bordering on Ductal Carcinoma In Situ|journal=International Journal of Surgical Pathology|volume=25|issue=2|year=2016|pages=100–107|issn=1066-8969|doi=10.1177/1066896916662154}}</ref></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*Size less than 2 mm.</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*Size less than 2 mm.</div></td></tr>
</table>
Mikael Häggström
https://patholines.org/index.php?title=Atypical_ductal_hyperplasia&diff=387&oldid=prev
Mikael Häggström: Started
2019-10-02T11:48:15Z
<p>Started</p>
<p><b>New page</b></p><div>{{Top<br />
|author1=[[User:Mikael Häggström|Mikael Häggström]]<br />
|author2=<br />
}}<br />
<br />
==Gross examination==<br />
As per:<br />
*[[Breast biopsy or excision]]<br />
or mastectomy.<br />
<br />
==Microscopic evaluation==<br />
[[File:Atypical ductal hyperplasia with immunotyping.jpg|thumb|300px|Histological appearance of atypical ductal hyperplasia (ADH) and immunohistochemical phenotype:<ref>{{cite journal|last1=Rageth|first1=Christoph J.|last2=Rubenov|first2=Ravit|last3=Bronz|first3=Cristian|last4=Dietrich|first4=Daniel|last5=Tausch|first5=Christoph|last6=Rodewald|first6=Ann-Katrin|last7=Varga|first7=Zsuzsanna|title=Atypical ductal hyperplasia and the risk of underestimation: tissue sampling method, multifocality, and associated calcification significantly influence the diagnostic upgrade rate based on subsequent surgical specimens|journal=Breast Cancer|volume=26|issue=4|year=2018|pages=452–458|issn=1340-6868|doi=10.1007/s12282-018-00943-2}} This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/)</ref> <br>- A - One focus (< 2 mm) of two architecturally disarranged cross sections of tubuli showing a monotonous intraductal proliferation with secondary intraluminal architecture. Hematoxylin and Eosin stain. <br>- B - One area of an ADH with associated calcifications intraluminal. Hematoxylin and Eosin stain. <br>- C - Higher magnification of ADH shows low-grade nuclear atypia and monotonous cell proliferation along with secondary intraluminal architecture. Hematoxylin and Eosin stain. <br>- D - Strong and uniform expression of estrogen receptors (ER). ER immunohistochemistry. <br>- E - Lack of basal cytokeratins (CK5/6). CK5/6 immunohistochemistry.]]<br />
Atypical ductal hyperplasia shows epithelial proliferations which are not qualitatively or quantitatively abnormal enough to be classified as ductal carcinoma in situ.<ref name=Statpearls-atypical>{{cite web|url=https://www.ncbi.nlm.nih.gov/books/NBK470258/|title=Atypical Breast Hyperplasia|author=David J. Myers; Andrew L. Walls.|website=StatPearls, National Center for Biotechnology Information}} Last Update: February 15, 2019.</ref><br />
<br />
There is no single definite cutoff that separates atypical ductal hyperplasia from [[ductal carcinoma in situ]], but the following are important distinctive features of atypical ductal hyperplasia, with suggested cutoffs:<ref name="TozbikianBrogi2016">{{cite journal|last1=Tozbikian|first1=Gary|last2=Brogi|first2=Edi|last3=Vallejo|first3=Christina E.|last4=Giri|first4=Dilip|last5=Murray|first5=Melissa|last6=Catalano|first6=Jeffrey|last7=Olcese|first7=Cristina|last8=Van Zee|first8=Kimberly J.|last9=Wen|first9=Hannah Yong|title=Atypical Ductal Hyperplasia Bordering on Ductal Carcinoma In Situ|journal=International Journal of Surgical Pathology|volume=25|issue=2|year=2016|pages=100–107|issn=1066-8969|doi=10.1177/1066896916662154}}</ref><br />
*Size less than 2 mm.<br />
*Not involving more than one duct.<br />
*The atypical epithelial proliferation is admixed with a second population of proliferative cells without atypia.<br />
*The proliferation completely involves the terminal ductal lobular unit(s), to a limited extent.<br />
{{Bottom}}</div>
Mikael Häggström