Benign non-inflammatory skin conditions

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Author: Mikael Häggström [note 1]
These are aberrations that do not display signs of suspected malignant excisions or dermatitis. These may present as skin cysts.



Generally 10% neutral buffered formalin.

  See also: General notes on fixation

Gross processing

Gross pathology processing of skin lesions with benign appearance, by lesion size:[1]
<4 mm 4 - 8 mm 9 - 15 mm




In table above, each top image shows recommended lines for cutting out slices to be submitted for further processing. Bottom image shows which side of the slice that should be put to microtomy. Dashed lines here mean that either side could be used. Further information: Gross processing of skin excisions

Microscopic evaluation

The primary objective is to determine the location, and then the most likely cell type of the aberration:



Fatty tissue


  1. For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.

Main page


  1. ". Ochsner J 5 (2): 22–33. 2003. PMID 22826680. PMC: 3399331. Archived from the original. . 
    - With a "standard histologic examination" that, in addition to the lesion, only includes one section from each side along the longest diameter of the specimen.
    - It also shows an example of circular coverage, with equal coverage distance in all four directions.
    - The entire specimen may be submitted if the risk of malignancy is high.
  2. Sato, Toshitsugu; Tanaka, Masaru (2014). "Linear sebaceous hyperplasia on the chest ". Dermatology Practical & Conceptual. doi:10.5826/dpc.0401a16. ISSN 21609381. 
  3. Rabello, FB; Souza, CD; Farina Jr, JA (2014). "Update on hypertrophic scar treatment ". Clinics 69 (8): 565–573. doi:10.6061/clinics/2014(08)11. ISSN 18075932. 

Image sources