Difference between revisions of "Bone"
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| − | {{Top | + | <noinclude>{{Top |
|author1=[[User:Mikael Häggström|Mikael Häggström]] | |author1=[[User:Mikael Häggström|Mikael Häggström]] | ||
|author2= | |author2= | ||
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==Subregions== | ==Subregions== | ||
*[[Bone marrow]] | *[[Bone marrow]] | ||
| + | |||
| + | ==Presentations== | ||
| + | *[[Osteomyelitis]] | ||
| + | *[[Toe]] | ||
| + | *[[Avascular necrosis]] | ||
| + | *'''Bone tumors''': Generally correlate with age, location and radiology. | ||
| + | </noinclude> | ||
| + | |||
| + | ==Grossing== | ||
| + | To submit slides for microscopy, generally gross as follows: | ||
| + | *'''Split''' the bone in the plane of interest for microscopy slides. | ||
| + | *'''Fix''' the bone in formalin. | ||
| + | *Perform '''decalcification''' of the specimen. First, generally take at least a small piece to be kept separately in formalin, in case the main specimen becomes necrotic, so that you have at least one more chance to decalcify it more lightly. | ||
| + | *Take the '''sections''' of interest. | ||
==Microscopic evaluation== | ==Microscopic evaluation== | ||
Look for any of the following: | Look for any of the following: | ||
<gallery> | <gallery> | ||
| − | File:Histopathology of acute osteomyelitis.jpg|Acute '''osteomyelitis''': Numerous neutrophils in the stroma. | + | File:Histopathology of acute osteomyelitis.jpg|Acute '''[[osteomyelitis]]''': Numerous neutrophils in the stroma. |
</gallery> | </gallery> | ||
| + | ===Metastasis=== | ||
| + | Highly suspicious [[prostate adenocarcinoma]] metastasis can be confirmed with NKX1, TTF1 and CDX2. | ||
{{Bottom}} | {{Bottom}} | ||
Latest revision as of 13:44, 2 January 2023
Author:
Mikael Häggström [note 1]
Contents
Subregions
Presentations
- Osteomyelitis
- Toe
- Avascular necrosis
- Bone tumors: Generally correlate with age, location and radiology.
Grossing
To submit slides for microscopy, generally gross as follows:
- Split the bone in the plane of interest for microscopy slides.
- Fix the bone in formalin.
- Perform decalcification of the specimen. First, generally take at least a small piece to be kept separately in formalin, in case the main specimen becomes necrotic, so that you have at least one more chance to decalcify it more lightly.
- Take the sections of interest.
Microscopic evaluation
Look for any of the following:
Acute osteomyelitis: Numerous neutrophils in the stroma.
Metastasis
Highly suspicious prostate adenocarcinoma metastasis can be confirmed with NKX1, TTF1 and CDX2.
Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
Image sources
