Bone
Revision as of 13:44, 2 January 2023 by Mikael Häggström (talk | contribs) (→Grossing: Take a small piece)
Author:
Mikael Häggström [note 1]
Contents
Subregions
Presentations
- Osteomyelitis
- Toe
- Avascular necrosis
- Bone tumors: Generally correlate with age, location and radiology.
Grossing
To submit slides for microscopy, generally gross as follows:
- Split the bone in the plane of interest for microscopy slides.
- Fix the bone in formalin.
- Perform decalcification of the specimen. First, generally take at least a small piece to be kept separately in formalin, in case the main specimen becomes necrotic, so that you have at least one more chance to decalcify it more lightly.
- Take the sections of interest.
Microscopic evaluation
Look for any of the following:
Acute osteomyelitis: Numerous neutrophils in the stroma.
Metastasis
Highly suspicious prostate adenocarcinoma metastasis can be confirmed with NKX1, TTF1 and CDX2.
Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
Image sources
