Bone marrow
Revision as of 16:11, 7 December 2021 by Mikael Häggström (talk | contribs) (→Bone marrow biopsy: NRBCs)
Author:
Mikael Häggström [note 1]
Contents
Autopsy
Microscopic evaluation
- Confirm trilineage hematopoiesis (see image).
- Look for apparent cellular atypia or decrease of cellular diversity.
Report
Example in a normal case:
Bone marrow from rib (or other location if applicable): Trilineage hematopoiesis. There is no evidence of malignancy. |
Bone marrow biopsy
Evaluate the following:
- Adequacy: There should preferably be 5 intertrabecular spaces.
- Cellularity: In patients 20-80 years, the percentage should be about 100 minus age, such as 40% in a 60 year old patient.
- Thrombopoiesis: There are normally about 3 megakaryocytes per 40x field.
- Myeloid/erythroid ratio, normally 3-4 myeloid cells per erythroid cell.
- Look for any granuloma or cancer metastasis
In a bone marrow count, nucleated red blood cells count into the total percentage of cells (but does not count into percentage of white blood cells in peripheral blood).
Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
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References
Image sources