Bone marrow
Author:
Mikael Häggström [note 1]
Contents
Autopsy
Microscopic evaluation
- Confirm trilineage hematopoiesis (see image).
- Look for apparent cellular atypia or decrease of cellular diversity.
Report
Example in a normal case:
| Bone marrow from rib (or other location if applicable): Trilineage hematopoiesis. There is no evidence of malignancy. |
Bone marrow aspirate
Perform a differential count by counting 500 cells[1] and dividing the numbers by 5 to get their percentages. Don't count cells that don't have a cytoplasm or nucleus.
Bone marrow biopsy
Evaluate the following:
- Adequacy: There should preferably be 5 intertrabecular spaces.
- Cellularity: In patients 20-80 years, the percentage should be about 100 minus age, such as 40% in a 60 year old patient.
- Thrombopoiesis: There are normally about 3 megakaryocytes per 40x field.
- Myeloid/erythroid ratio, normally 3-4 myeloid cells per erythroid cell.
- Look for any granuloma or cancer metastasis
In a bone marrow count, nucleated red blood cells count into the total percentage of cells (but does not count into percentage of white blood cells in peripheral blood).
Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ Abdulrahman AA, Patel KH, Yang T, Koch DD, Sivers SM, Smith GH (2018). "Is a 500-Cell Count Necessary for Bone Marrow Differentials?: A Proposed Analytical Method for Validating a Lower Cutoff. ". Am J Clin Pathol 150 (1): 84-91. doi:. PMID 29757362. Archived from the original. .
Image sources
