Chronic appendicitis

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Author: Mikael Häggström [note 1]
Chronic appendicitis (including peri-appendicitis):


Generally 10% neutral buffered formalin.

  See also: General notes on fixation


On this resource, the following formatting is used for comprehensiveness:

  • Minimal depth
  • (Moderate depth)
  • ((Comprehensive))

Gross processing

Further information: Appendix A major visual clue to chronic appendicitis is fibrosis.[1]

(When the referral and/or history suggests chronic appendicitis, take additional slices for microscopy.)[notes 1]

Microscopic evaluation

Patchy chronic peri-appendicitis.

Further information: Appendicitis Chronic appendicitis has predominantly mononuclear infiltrate rather than neutrophilic.[1] It must go beyond the normal histological locations of mononuclear leucocytes of the appendix.

Even when chronic appendicitis is detected, also look for acute appendicitis, as well as appendix cancer.(Further information: Appendix )

Microscopy report

(Note even the absence of acute appendicitis.)


Histopathology of patchy chronic peri-appendicitis.jpg
Patchy chronic peri-appendicitis. (Negative for acute inflammation.)


  1. It will require additional slices to comfortably rule out acute appendicitis.
  1. For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.

Main page


  1. 1.0 1.1 Sierakowski, Kyra; Pattichis, Andrew; Russell, Patrick; Wattchow, David (2016). "Unusual presentation of a familiar pathology: chronic appendicitis ". BMJ Case Reports: bcr2015212485. doi:10.1136/bcr-2015-212485. ISSN 1757-790X. 

Image sources