Difference between revisions of "Clear cell renal cell carcinoma"

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==Microscopy report==
 
==Microscopy report==
*Diagnosis of clear cell renal cell carcinoma
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There should preferably be a free text report and a synoptic report, the free text report including:
*Greatest dimension (from grossing)
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*'''Diagnosis''' of clear cell renal cell carcinoma
*ISUP/WHO grade
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*Greatest '''dimension''' (from grossing)
*Radicality
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*'''ISUP/WHO grade'''
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*'''Radicality'''
  
 
Example:
 
Example:
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*Surgical margins are negative for carcinoma.
 
*Surgical margins are negative for carcinoma.
 
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The synoptic report should include:<ref name=stora/>
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*Total or partial nephrectomy
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*In nephrectomy: Location
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*Size
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*Relationship to capsule, perinephric tissues, renal pelvis, adrenal gland and hilar blood vessels
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*Histological type
 +
*Degree of differentiation
 +
*Radicality
 +
*Any lymph node metastases
 +
 
{{Bottom}}
 
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Revision as of 20:34, 1 December 2020

Author: Mikael Häggström [note 1]
Clear cell renal cell carcinoma (CCRCC):

Gross processing

As per: Kidney with tumor

Microscopic examination

Clear cell renal cell carcinoma.

CCRCC typically shows cells in nests or solid pattern, and a delicate branching fibrovascular network.[1]

Differential diagnosis: Kidney with tumor
If unsure, useful immunohistochemistry markers that are positive in CCRCC are vimentin, EMA, keratin, CD10, Pax2, RCC, CAIX (circumferential membranous).[1]

Grading

CCRCCs are graded by the ISUP/WHO as follows:[2][3]

  • Grade 1: Inconspicuous and basophilic nucleoli at ×400 magnification
  • Grade 4: Extreme pleomorphism or rhabdoid and/or sarcomatoid morphology

Microscopy report

There should preferably be a free text report and a synoptic report, the free text report including:

  • Diagnosis of clear cell renal cell carcinoma
  • Greatest dimension (from grossing)
  • ISUP/WHO grade
  • Radicality

Example:

Kidney, left, partial nephrectomy:
  • Clear cell renal cell carcinoma, 3.2 cm in greatest dimension, ISUP/WHO grade 3.
  • Surgical margins are negative for carcinoma.

The synoptic report should include:[4]

  • Total or partial nephrectomy
  • In nephrectomy: Location
  • Size
  • Relationship to capsule, perinephric tissues, renal pelvis, adrenal gland and hilar blood vessels
  • Histological type
  • Degree of differentiation
  • Radicality
  • Any lymph node metastases

Notes

  1. For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.

Main page

References

  1. 1.0 1.1 Sirohi, Deepika; Smith, Steven C.; Agarwal, Neeraj; Maughan, Benjamin L. (2018). "Unclassified renal cell carcinoma: diagnostic difficulties and treatment modalities ". Research and Reports in Urology Volume 10: 205–217. doi:10.2147/RRU.S154932. ISSN 2253-2447. 
  2. YiFen Zhang. What is the ISUP/WHO grading system for renal cell carcinoma (RCC)?. Medscape. Updated: Jul 02, 2019
  3. Moch, H. (2016). "WHO-ISUP-Graduierungssystem für Nierenkarzinome ". Der Pathologe 37 (4): 355–360. doi:10.1007/s00292-016-0171-y. ISSN 0172-8113. 
  4. Cite error: Invalid <ref> tag; no text was provided for refs named stora

Image sources