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Author: Mikael Häggström [note 1]


On this resource, the following formatting is used for comprehensiveness:

  • Minimal depth
  • (Moderate depth)
  • ((Comprehensive))

Gross processing

  • Inspect
  • Measure
  • Serially section in 3-4 mm wide slices.

Example gross report:

(Labeled: ___. The specimen is received in formalin and consists of an) << opaque / translucent>> corneal disc measuring __ cm in diameter and __ cm in thickness. The specimen is serially sectioned and entirely submitted for microscopic examination in one cassette.

Microscopic examination

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Corneal subepithelial acute inflammation, seen as the presence of neutrophils, as well as chronic inflammation, seen as plasma cells and lymphocytes. There is an associated neovascularization. Bowman's membrane is disrupted. The findings are non-specific.

Look for integrity of Bowman's and Descemet's membranes.

For corneal opacities, look for the most common causes, which generally manifest as:[1]

  • Inflammation and edema
  • Traumatic injury



Histopathology of corneal acute and chronic inflammation.jpg

(Right eye cornea, excision:
Cornea with)
patchy acute and chronic inflammation, nonspecific, with disrupted Bowman's membrane and associated neovascularization.


  1. For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.

Main page


  1. Michael Woods (2018). Corneal Opacity. Winchester Hospital, MA.

Image sources