Duodenum
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Common requests
Microscopic examination
Generally look for:
- Signs of peptic duodenitis
- Intra-epithelial lymphocytes
- Tumors
- Giardia organisms
Peptic injury
Peptic injury[note 2] typically showing the following:[1]
Others
Intra-epithelial lymphocytes (IELs) is the main finding in celiac disease (even in earliest stage)[2],[images 1] and is best evaluated at tips of villi[3].
25 - 29 IEL/100 enterocytes is considered borderline.[4]
> 30 IEL/100 enterocytes represents a pathological lymphocytosis.[4]Tumors (leiomyoma pictured): evaluate as per intestine with tumor
Report
Example in a normal case:
(Duodenum, biopsy:)
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Example in (chronic) peptic injury:
(Small bowel, biopsy:)
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Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
- ↑ Peptic injury is also called peptic duodenitis, but "duodenitis" may be reserved for cases with an inflammatory infiltrate.
Main page
References
- ↑ Hasan Samra, M.D., Mohamed Mostafa, M.D.. Small intestine & ampulla - Inflammatory disorders - Peptic duodenitis. Pathology Outlines. Topic Completed: 13 April 2020. Minor changes: 13 April 2020
- ↑ "Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue') ". Gastroenterology 102 (1): 330–54. 1992. doi: . PMID 1727768.
- ↑ Biagi F, Luinetti O, Campanella J, Klersy C, Zambelli C, Villanacci V (2004). "Intraepithelial lymphocytes in the villous tip: do they indicate potential coeliac disease? ". J Clin Pathol 57 (8): 835-9. doi: . PMID 15280404. PMC: 1770380. Archived from the original. .
- ↑ 4.0 4.1 Juwairiya Arshi, M.B.B.S., Aaron R. Huber, D.O.. Small intestine & ampulla. Malabsorption. Celiac sprue. Pathology Outlines. Retrieved on 2022-04-04.
Image sources
- ↑ "Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue')
". Gastroenterology 102 (1): 330–54. 1992. doi: . PMID 1727768.
- Figure 2- available via license: Creative Commons Attribution 2.0 Generic license.