Endometrial curettings
Author:
Mikael Häggström [note 1]
Contents
Grossing
- Generally submit all tissue for microscopy, even larger volumes.
- Look for products of conception if indicated from referral and/or history
Microscopy
Look mainly for:
- Signs of endometrial hyperplasia.
- Products of conception if indicated from referral and/or history
- Hyperplasia, atypa and/or malignancy
Hyperplasia, atypa and/or malignancy
Complex hyperplasia without atypia: Cystically dilated endometrial glands lined by a single layer of columnar epithelium.[1]
Complex hyperplasia with atypia: Closely packed endometrial glands with sparse intervening stroma and stratification of the lining epithelium. Epithelial cells show cytological atypia with high nucleocytoplasmic ratio, irregular clumping of nuclear chromatin, and mitotic figures.[2]
Endometrial adenocarcinoma[3], most commonly endometrioid, in which case low-grade carcinoma is distinguished from hyperplasia with atypia by the presence of glandular crowding with endometrial stromal exclusion, and significant cribriform, confluent glandular, labyrinthine, papillary/villoglandular, or non-squamous solid architecture.[4]
Microscopy report
Example in a normal case:
(Optionally: Benign endometrium and endocervical mucosa without significant histopathologic changes.) Negative for neoplasia or viral cytopathic changes. |
Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ Rao, Shalinee; Sundaram, Sandhya; Narasimhan, Raghavan (2009). "Biological behavior of preneoplastic conditions of the endometrium: A retrospective 16-year study in south India
". Indian Journal of Medical and Paediatric Oncology 30 (4): 131. doi: . ISSN 0971-5851.
- Figure- available via license: Creative Commons Attribution 2.0 Generic - ↑ Rao, Shalinee; Sundaram, Sandhya; Narasimhan, Raghavan (2009). "Biological behavior of preneoplastic conditions of the endometrium: A retrospective 16-year study in south India
". Indian Journal of Medical and Paediatric Oncology 30 (4): 131. doi: . ISSN 0971-5851.
- Figure- available via license: Creative Commons Attribution 2.0 Generic - ↑ Stewart, Colin J.R.; Crum, Christopher P.; McCluggage, W. Glenn; Park, Kay J.; Rutgers, Joanne K.; Oliva, Esther; Malpica, Anais; Parkash, Vinita; et al. (2019). "Guidelines to Aid in the Distinction of Endometrial and Endocervical Carcinomas, and the Distinction of Independent Primary Carcinomas of the Endometrium and Adnexa From Metastatic Spread Between These and Other Sites
". International Journal of Gynecological Pathology 38: S75–S92. doi: . ISSN 0277-1691.
- "Figures - available via license: Creative Commons Attribution 4.0 International" - ↑ Rabban, Joseph T.; Gilks, C. Blake; Malpica, Anais; Matias-Guiu, Xavier; Mittal, Khush; Mutter, George L.; Oliva, Esther; Parkash, Vinita; et al. (2019). "Issues in the Differential Diagnosis of Uterine Low-grade Endometrioid Carcinoma, Including Mixed Endometrial Carcinomas ". International Journal of Gynecological Pathology 38: S25–S39. doi: . ISSN 0277-1691.
Image sources