Difference between revisions of "Endometrial polyp"
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{{Fixation - general notes}} | {{Fixation - general notes}} | ||
==Microscopic evaluation== | ==Microscopic evaluation== | ||
| − | [[File:Endometrial histopathologies and cytopathologies.jpg|thumb| | + | [[File:Endometrial histopathologies and cytopathologies.jpg|thumb|420px|Histopathologic and cytopathologic images.<br>(A) '''proliferative''' endometrium (Left: HE × 400) and proliferative endometrial cells (Right: HE × 100)<br>(B) '''secretory''' endometrium (Left: HE × 10) and secretory endometrial cells (Right: HE × 10)<br>(C) '''atrophic''' endometrium (Left: HE × 10) and atrophic endometrial cells (Right: HE × 10)<br>(D) '''mixed''' endometrium (Left: HE × 10) and mixed endometrial cells (Right: HE × 10)<br>(E): endometrial '''atypical hyperplasia''' (Left: HE × 10) and endometrial atypical cells (Right: HE × 200)<br>(F) '''endometrial carcinoma''' (Left: HE × 400) and endometrial cancer cells (Right: HE × 400).]] |
The main objectives are: | The main objectives are: | ||
*Confirm an endometrioid polyp. | *Confirm an endometrioid polyp. | ||
*Look for signs of atypia or malignancy. | *Look for signs of atypia or malignancy. | ||
| − | <gallery mode=packed> | + | <gallery mode=packed heights=200> |
File:Histopathology of non-complex endometrial polyp without atypia.jpg|'''Non-complex endometrial polyp without atypia''', with a thick-walled blood vessel in middle - typical of endometrial polyps. Glands are regular. | File:Histopathology of non-complex endometrial polyp without atypia.jpg|'''Non-complex endometrial polyp without atypia''', with a thick-walled blood vessel in middle - typical of endometrial polyps. Glands are regular. | ||
File:Histopathology of non-complex endometrial polyp without atypia, with tubal metaplasia.jpg|'''Non-complex endometrial polyp without atypia''', with tubal metaplasia (black arrow) and a thick-walled blood vessel (white arrow). The stroma is hemorrhagic. | File:Histopathology of non-complex endometrial polyp without atypia, with tubal metaplasia.jpg|'''Non-complex endometrial polyp without atypia''', with tubal metaplasia (black arrow) and a thick-walled blood vessel (white arrow). The stroma is hemorrhagic. | ||
Revision as of 08:45, 2 March 2020
Author:
Mikael Häggström [note 1]
Contents
Fixation
Generally 10% neutral buffered formalin.
See also: General notes on fixation
Microscopic evaluation
Histopathologic and cytopathologic images.
(A) proliferative endometrium (Left: HE × 400) and proliferative endometrial cells (Right: HE × 100)
(B) secretory endometrium (Left: HE × 10) and secretory endometrial cells (Right: HE × 10)
(C) atrophic endometrium (Left: HE × 10) and atrophic endometrial cells (Right: HE × 10)
(D) mixed endometrium (Left: HE × 10) and mixed endometrial cells (Right: HE × 10)
(E): endometrial atypical hyperplasia (Left: HE × 10) and endometrial atypical cells (Right: HE × 200)
(F) endometrial carcinoma (Left: HE × 400) and endometrial cancer cells (Right: HE × 400).
(A) proliferative endometrium (Left: HE × 400) and proliferative endometrial cells (Right: HE × 100)
(B) secretory endometrium (Left: HE × 10) and secretory endometrial cells (Right: HE × 10)
(C) atrophic endometrium (Left: HE × 10) and atrophic endometrial cells (Right: HE × 10)
(D) mixed endometrium (Left: HE × 10) and mixed endometrial cells (Right: HE × 10)
(E): endometrial atypical hyperplasia (Left: HE × 10) and endometrial atypical cells (Right: HE × 200)
(F) endometrial carcinoma (Left: HE × 400) and endometrial cancer cells (Right: HE × 400).
The main objectives are:
- Confirm an endometrioid polyp.
- Look for signs of atypia or malignancy.
Non-complex endometrial polyp without atypia, with a thick-walled blood vessel in middle - typical of endometrial polyps. Glands are regular.
Non-complex endometrial polyp without atypia, with tubal metaplasia (black arrow) and a thick-walled blood vessel (white arrow). The stroma is hemorrhagic.
Complex hyperplasia without atypia: Cystically dilated endometrial glands lined by a single layer of columnar epithelium.[1]
Complex hyperplasia with atypia: Closely packed endometrial glands with sparse intervening stroma and stratification of the lining epithelium. Epithelial cells show cytological atypia with high nucleocytoplasmic ratio, irregular clumping of nuclear chromatin, and mitotic figures.[2]
Subserosal pedunculated uterine leiomyomas may present as endometrial polyps. They typically show smooth muscle in a whorled (fascicular) pattern[3] Further information: Smooth muscle tumor
Reporting
Most importantly:
- Presence or absence of atypia.
Optionally, report the type of epithelium at both the surface and gland coverings.
See also: General notes on reporting
Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ Rao, Shalinee; Sundaram, Sandhya; Narasimhan, Raghavan (2009). "Biological behavior of preneoplastic conditions of the endometrium: A retrospective 16-year study in south India
". Indian Journal of Medical and Paediatric Oncology 30 (4): 131. doi:. ISSN 0971-5851.
- Figure- available via license: Creative Commons Attribution 2.0 Generic - ↑ Rao, Shalinee; Sundaram, Sandhya; Narasimhan, Raghavan (2009). "Biological behavior of preneoplastic conditions of the endometrium: A retrospective 16-year study in south India
". Indian Journal of Medical and Paediatric Oncology 30 (4): 131. doi:. ISSN 0971-5851.
- Figure- available via license: Creative Commons Attribution 2.0 Generic - ↑ Mohamed Mokhtar Desouki. Uterus - Stromal tumors - Leiomyoma. pathology Outlines. Topic Completed: 1 August 2011. Revised: 15 December 2019
Image sources
