Difference between revisions of "Endometrial thickening"

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m (Mikael Häggström moved page Endometrial hyperplasia to Endometrial thickening: Finding-based)
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==Microscopic evaluation==
 
==Microscopic evaluation==
[[File:Endometrial histopathologies and cytopathologies.jpg|thumb|400px|Histopathologic and cytopathologic images.<br>(A) proliferative endometrium (Left: HE × 400) and proliferative endometrial cells (Right: HE × 100)<br>(B) secretory endometrium (Left: HE × 10) and secretory endometrial cells (Right: HE × 10)<br>(C) atrophic endometrium (Left: HE × 10) and atrophic endometrial cells (Right: HE × 10)<br>(D) mixed endometrium (Left: HE × 10) and mixed endometrial cells (Right: HE × 10)<br>(E): endometrial atypical hyperplasia (Left: HE × 10) and endometrial atypical cells (Right: HE × 200)<br>(F) endometrial carcinoma (Left: HE × 400) and endometrial cancer cells (Right: HE × 400).]]
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[[File:Endometrial histopathologies and cytopathologies.jpg|thumb|400px|Histopathologic and cytopathologic images.<br>(A) proliferative endometrium (Left: HE × 400) and proliferative endometrial cells (Right: HE × 100)<br>(B) secretory endometrium (Left: HE × 10) and secretory endometrial cells (Right: HE × 10)<br>(C) atrophic endometrium (Left: HE × 10) and atrophic endometrial cells (Right: HE × 10)<br>(D) mixed endometrium (Left: HE × 10) and mixed endometrial cells (Right: HE × 10)<br>(E): endometrial atypical hyperplasia (Left: HE × 10) and endometrial atypical cells (Right: HE × 200)<br>(F) '''[[endometrial carcinoma]]''' (Left: HE × 400) and endometrial cancer cells (Right: HE × 400).]]
 
*Look for signs of atypia or malignancy.
 
*Look for signs of atypia or malignancy.
 
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<gallery mode=packed>

Revision as of 09:39, 30 August 2021

Author: Mikael Häggström [note 1]

Fixation

Generally 10% neutral buffered formalin.

  See also: General notes on fixation


Hysterectomy sampling

A regular hysterectomy grossing is performed, but with the following sampling:[1]

  • 2 longitudinal sections through ecto/endocervix (1 anterior and 1 posterior)
  • 2 longitudinal sections through upper endocervix/lower uterine segment (1 anterior and 1 posterior), immediately adjacent to the sections taken from the cervix
  • 4 full-thickness representative sections of endomyometrium (2 anterior and 2 posterior)
  • Transversely section the remaining anterior and posterior endomyometrium (~1 cm thick). Submit the entire endometrium from the lower uterine segment to the fundus, maintaining orientation.
  • Submit entire fimbriae (longitudinally sectioned) and 2 representative cross-sections on each side.

Microscopic evaluation

Histopathologic and cytopathologic images.
(A) proliferative endometrium (Left: HE × 400) and proliferative endometrial cells (Right: HE × 100)
(B) secretory endometrium (Left: HE × 10) and secretory endometrial cells (Right: HE × 10)
(C) atrophic endometrium (Left: HE × 10) and atrophic endometrial cells (Right: HE × 10)
(D) mixed endometrium (Left: HE × 10) and mixed endometrial cells (Right: HE × 10)
(E): endometrial atypical hyperplasia (Left: HE × 10) and endometrial atypical cells (Right: HE × 200)
(F) endometrial carcinoma (Left: HE × 400) and endometrial cancer cells (Right: HE × 400).
  • Look for signs of atypia or malignancy.

Reporting

Most importantly:

  • Presence or absence of atypia.

  See also: General notes on reporting


Notes

  1. For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.

Main page

References

  1. Nicole Cipriani (2020-06-22). Gross Pathology Manual. The University of Chicago Department of Pathology.
  2. Rao, Shalinee; Sundaram, Sandhya; Narasimhan, Raghavan (2009). "Biological behavior of preneoplastic conditions of the endometrium: A retrospective 16-year study in south India ". Indian Journal of Medical and Paediatric Oncology 30 (4): 131. doi:10.4103/0971-5851.65335. ISSN 0971-5851. 
    - Figure- available via license: Creative Commons Attribution 2.0 Generic
  3. Rao, Shalinee; Sundaram, Sandhya; Narasimhan, Raghavan (2009). "Biological behavior of preneoplastic conditions of the endometrium: A retrospective 16-year study in south India ". Indian Journal of Medical and Paediatric Oncology 30 (4): 131. doi:10.4103/0971-5851.65335. ISSN 0971-5851. 
    - Figure- available via license: Creative Commons Attribution 2.0 Generic

Image sources