Endometrial thickening
Revision as of 09:35, 30 August 2021 by Mikael Häggström (talk | contribs) (Mikael Häggström moved page Endometrial hyperplasia to Endometrial thickening: Finding-based)
Author:
Mikael Häggström [note 1]
Contents
Fixation
Generally 10% neutral buffered formalin.
See also: General notes on fixation
Hysterectomy sampling
A regular hysterectomy grossing is performed, but with the following sampling:[1]
- 2 longitudinal sections through ecto/endocervix (1 anterior and 1 posterior)
- 2 longitudinal sections through upper endocervix/lower uterine segment (1 anterior and 1 posterior), immediately adjacent to the sections taken from the cervix
- 4 full-thickness representative sections of endomyometrium (2 anterior and 2 posterior)
- Transversely section the remaining anterior and posterior endomyometrium (~1 cm thick). Submit the entire endometrium from the lower uterine segment to the fundus, maintaining orientation.
- Submit entire fimbriae (longitudinally sectioned) and 2 representative cross-sections on each side.
Microscopic evaluation
- Look for signs of atypia or malignancy.
Complex hyperplasia without atypia: Cystically dilated endometrial glands lined by a single layer of columnar epithelium.[2]
Complex hyperplasia with atypia: Closely packed endometrial glands with sparse intervening stroma and stratification of the lining epithelium. Epithelial cells show cytological atypia with high nucleocytoplasmic ratio, irregular clumping of nuclear chromatin, and mitotic figures.[3]
Reporting
Most importantly:
- Presence or absence of atypia.
See also: General notes on reporting
Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ Nicole Cipriani (2020-06-22). Gross Pathology Manual. The University of Chicago Department of Pathology.
- ↑ Rao, Shalinee; Sundaram, Sandhya; Narasimhan, Raghavan (2009). "Biological behavior of preneoplastic conditions of the endometrium: A retrospective 16-year study in south India
". Indian Journal of Medical and Paediatric Oncology 30 (4): 131. doi: . ISSN 0971-5851.
- Figure- available via license: Creative Commons Attribution 2.0 Generic - ↑ Rao, Shalinee; Sundaram, Sandhya; Narasimhan, Raghavan (2009). "Biological behavior of preneoplastic conditions of the endometrium: A retrospective 16-year study in south India
". Indian Journal of Medical and Paediatric Oncology 30 (4): 131. doi: . ISSN 0971-5851.
- Figure- available via license: Creative Commons Attribution 2.0 Generic
Image sources