Difference between revisions of "Fibrocystic breast changes"
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*Have no myoepithelial cells surrounding duccts. | *Have no myoepithelial cells surrounding duccts. | ||
| − | When unsure, perform immunohistochemistry for calponin: | + | When unsure, perform immunohistochemistry for '''calponin''': |
[[File:Chromogenic immunohistochemistry for calponin in sclerosing adenosis.jpg|thumb|center|Immunostain for caplonin in sclerosing adenosis, showing myoepithelial cells surrounding the ducts, thereby excluding invasive carcinoma.]] | [[File:Chromogenic immunohistochemistry for calponin in sclerosing adenosis.jpg|thumb|center|Immunostain for caplonin in sclerosing adenosis, showing myoepithelial cells surrounding the ducts, thereby excluding invasive carcinoma.]] | ||
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Revision as of 17:52, 18 February 2021
Author:
Mikael Häggström [note 1]
Contents
Presentations
Microscopic examination
Types:
Sclerosing adenosis, with an increase in glandular elements in addition to stromal proliferation that distorts and compresses glands.[1]
Differential diagnosis
Sclerosing adenosis may look similar to invasive ductal carcinoma (IDC), but IDC will:[1]
- Not be lobular at low power
- Have marked cellular atypia
- Have no myoepithelial cells surrounding duccts.
When unsure, perform immunohistochemistry for calponin:
Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ 1.0 1.1 Jaya Ruth Asirvatham, M.B.B.S., Julie M. Jorns, M.D.. Breast - Fibrocystic changes - Sclerosing adenosis. Pathology Outlines. Topic Completed: 1 January 2015. Minor changes: 31 December 2020
Image sources
