Difference between revisions of "Fibrocystic breast changes"

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When unsure, perform immunohistochemistry for '''calponin''':
 
When unsure, perform immunohistochemistry for '''calponin''':
[[File:Chromogenic immunohistochemistry for calponin in sclerosing adenosis.jpg|thumb|center|Immunostain with a {{myoepithelial marker}} (calponin) in sclerosing adenosis, showing myoepithelial cells surrounding the ducts, thereby excluding invasive carcinoma.]]
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[[File:Chromogenic immunohistochemistry for calponin in sclerosing adenosis.jpg|thumb|center|Immunostain with a myoepithelial marker{{myoepithelial marker}} (calponin) in sclerosing adenosis, showing myoepithelial cells surrounding the ducts, thereby excluding invasive carcinoma.]]
  
 
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Revision as of 09:53, 10 February 2022

Author: Mikael Häggström [note 1]

Presentations

Microscopic examination

Types:

Differential diagnosis

Sclerosing adenosis may look similar to invasive ductal carcinoma (IDC), but IDC will:[1]

  • Not be lobular at low power
  • Have marked cellular atypia
  • Have no myoepithelial cells surrounding ducts.

When unsure, perform immunohistochemistry for calponin:

Immunostain with a myoepithelial markerTemplate:Myoepithelial marker (calponin) in sclerosing adenosis, showing myoepithelial cells surrounding the ducts, thereby excluding invasive carcinoma.

Notes

  1. For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.

Main page

References

  1. 1.0 1.1 Jaya Ruth Asirvatham, M.B.B.S., Julie M. Jorns, M.D.. Breast - Fibrocystic changes - Sclerosing adenosis. Pathology Outlines. Topic Completed: 1 January 2015. Minor changes: 31 December 2020

Image sources