Difference between revisions of "Fibrocystic breast changes"
Jump to navigation
Jump to search
m (→Differential diagnosis: note) |
(→Differential diagnosis: Displayed) |
||
Line 19: | Line 19: | ||
*Have no myoepithelial cells surrounding ducts. | *Have no myoepithelial cells surrounding ducts. | ||
− | When unsure, perform immunohistochemistry for '''calponin''': | + | When unsure, perform immunohistochemistry for myoepithelial markers (preferably '''p63''' and '''calponin''' in breast lesions): |
− | [[File:Chromogenic immunohistochemistry for calponin in sclerosing adenosis.jpg|thumb|center|Immunostain with a myoepithelial marker | + | [[File:Chromogenic immunohistochemistry for calponin in sclerosing adenosis.jpg|thumb|center|Immunostain with a myoepithelial marker (calponin) in sclerosing adenosis, showing myoepithelial cells surrounding the ducts, thereby excluding invasive carcinoma.]] |
{{Bottom}} | {{Bottom}} |
Revision as of 08:27, 25 April 2022
Author:
Mikael Häggström [note 1]
Contents
Presentations
Microscopic examination
Types:
Sclerosing adenosis, with an increase in glandular elements in addition to stromal proliferation that distorts and compresses glands.[1]
Differential diagnosis
Sclerosing adenosis may look similar to invasive ductal carcinoma (IDC), but IDC will:[1]
- Not be lobular at low power
- Have marked cellular atypia
- Have no myoepithelial cells surrounding ducts.
When unsure, perform immunohistochemistry for myoepithelial markers (preferably p63 and calponin in breast lesions):
Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ 1.0 1.1 Jaya Ruth Asirvatham, M.B.B.S., Julie M. Jorns, M.D.. Breast - Fibrocystic changes - Sclerosing adenosis. Pathology Outlines. Topic Completed: 1 January 2015. Minor changes: 31 December 2020
Image sources