Difference between revisions of "Fibrocystic breast changes"

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===Differential diagnosis===
 
===Differential diagnosis===
Sclerosing adenosis may look similar to [[invasive ductal carcinoma]] (IDC), but IDC will:<ref name=PathologyOutlines/>
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Sclerosing adenosis may look similar to [[invasive ductal carcinoma]] (IDC), but IDC will:<ref name=PathologyOutlines-fibrocystic/>
 
*Not be lobular at low power
 
*Not be lobular at low power
 
*Have marked cellular atypia
 
*Have marked cellular atypia

Revision as of 17:59, 19 June 2022

Author: Mikael Häggström [note 1]

Presentations

Microscopic examination

Types:

Differential diagnosis

Sclerosing adenosis may look similar to invasive ductal carcinoma (IDC), but IDC will:[1]

  • Not be lobular at low power
  • Have marked cellular atypia
  • Have no myoepithelial cells surrounding ducts.

When unsure, perform immunohistochemistry for myoepithelial markers (preferably p63 and calponin in breast lesions):

Immunostain with a myoepithelial marker (calponin) in sclerosing adenosis, showing myoepithelial cells surrounding the ducts, thereby excluding invasive carcinoma.

Notes

  1. For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.

Main page

References

  1. 1.0 1.1 Jaya Ruth Asirvatham, M.B.B.S., Julie M. Jorns, M.D.. Breast - Fibrocystic changes - Sclerosing adenosis. Pathology Outlines. Topic Completed: 1 January 2015. Minor changes: 31 December 2020

Image sources