Difference between revisions of "Gastritis"

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Inflammation of the [[stomach]]:
 
Inflammation of the [[stomach]]:
 
==Microscopy evaluation==
 
==Microscopy evaluation==
[[File:Histopathology of mild active gastritis, annotated.jpg|thumb|Histopathology of '''mild active gastritis''', with intraepithelial neutrophils (white arrows) as well as in lamina propria (black arrows).]]
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[[File:Histopathology of mild active gastritis, annotated.jpg|thumb|230pxHistopathology of '''mild active gastritis''', with intraepithelial neutrophils (white arrows) as well as in lamina propria (black arrows).]]
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[[File:Updated Sydney System for visual classification of gastritis.png|thumb|260px|Updated Sydney System for visual classification of gastritis.<ref name=Carrasco/>]]
 
*'''Mild acute gastritis:'''<ref name=PathologyOutlinesAcute>{{cite web|url=https://www.pathologyoutlines.com/topic/stomachacutegastritis.html|title=Stomach - Gastritis - Acute gastritis|author=Elliot Weisenberg|website=pathologyOutlines}} Topic Completed: 1 August 2012. Minor changes: 31 August 2020</ref>
 
*'''Mild acute gastritis:'''<ref name=PathologyOutlinesAcute>{{cite web|url=https://www.pathologyoutlines.com/topic/stomachacutegastritis.html|title=Stomach - Gastritis - Acute gastritis|author=Elliot Weisenberg|website=pathologyOutlines}} Topic Completed: 1 August 2012. Minor changes: 31 August 2020</ref>
 
:*Modest '''edema''' of lamina propria
 
:*Modest '''edema''' of lamina propria
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:*Mucosal '''hemorrhage'''
 
:*Mucosal '''hemorrhage'''
 
:*Intact epithelium
 
:*Intact epithelium
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<gallery mode=packed heights=180px>
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File:Histopathology of early acute superficial gastritis.png|Early acute superficial gastritis: Marked neutrophilic infiltrates appear in the mucous neck region and lamina with a pit micoabscess.<ref name=Carrasco>{{cite journal| author=Carrasco G, Corvalan AH| title=Helicobacter pylori-Induced Chronic Gastritis and Assessing Risks for Gastric Cancer. | journal=Gastroenterol Res Pract | year= 2013 | volume= 2013 | issue=  | pages= 393015 | pmid=23983680 | doi=10.1155/2013/393015 | pmc=3745848 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23983680  }}<br>[https://www.researchgate.net/publication/256190376_Helicobacter_pylori-Induced_Chronic_Gastritis_and_Assessing_Risks_for_Gastric_Cancer Figures - available via license: Creative Commons Attribution 3.0 Unported]</ref>
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</gallery>
 
*'''Moderate to severe acute gastritis''':<ref name=PathologyOutlinesAcute/>
 
*'''Moderate to severe acute gastritis''':<ref name=PathologyOutlinesAcute/>
 
:*'''Loss of superficial epithelium''' above the muscularis mucosa
 
:*'''Loss of superficial epithelium''' above the muscularis mucosa

Revision as of 16:41, 18 September 2021

Author: Mikael Häggström [note 1]

Inflammation of the stomach:

Microscopy evaluation

230pxHistopathology of mild active gastritis, with intraepithelial neutrophils (white arrows) as well as in lamina propria (black arrows).
Updated Sydney System for visual classification of gastritis.[1]
  • Mild acute gastritis:[2]
  • Modest edema of lamina propria
  • Vascular congestion
  • Scattered neutrophils
  • Mucosal hemorrhage
  • Intact epithelium
  • Moderate to severe acute gastritis:[2]
  • Loss of superficial epithelium above the muscularis mucosa
  • Hemorrhage
  • Variable infiltrate with neutrophils
  • Fibrinopurulent luminal exudate
  • Nearby epithelium may show regenerative changes
  • Chronic gastritis[3]
Mucosal plasma cell infiltrate in mild chronic gastritis.
  • Presence of plasma cells, lymphocytes, and occasionally lymphoid follicles. Eosinophils and neutrophils may be present.
  • Reduced mucin in the cytoplasm
  • Enlargement of nuclei and nucleoi
  • Subnuclear vacuolation in antral glands or pits (which is PAS negative)
  • Intestinal metaplasia: with partial replacement of the mucosa of the antrum and body with metaplastic goblet cells of intestinal morphology, absorptive cells and Paneth cells.

When gastritis is present, also evaluate as a stomach biopsy for Helicobacter pylori.

Microscopy report

Chronic gastritis without neutrophils is preferably also termed "non-active".

Example:

(Gastric, biopsy:) Mild chronic non-active gastritis, non-specific. Negative for Helicobacter pylori organisms on H&E slide.

Notes

  1. For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.

Main page

References

  1. 1.0 1.1 Carrasco G, Corvalan AH (2013). "Helicobacter pylori-Induced Chronic Gastritis and Assessing Risks for Gastric Cancer. ". Gastroenterol Res Pract 2013: 393015. doi:10.1155/2013/393015. PMID 23983680. PMC: 3745848. Archived from the original. . 
    Figures - available via license: Creative Commons Attribution 3.0 Unported
  2. 2.0 2.1 Elliot Weisenberg. Stomach - Gastritis - Acute gastritis. pathologyOutlines. Topic Completed: 1 August 2012. Minor changes: 31 August 2020
  3. Elliot Weisenberg. Stomach - Gastritis - Chronic gastritis. PathologyOutlines. Topic Completed: 1 August 2012. Minor changes: 31 August 2020

Image sources