Generally 10% neutral buffered formalin.
See also: General notes on fixation
On this resource, the following formatting is used for comprehensiveness:
- Minimal depth
- (Moderate depth)
- Perform consecutive slicing of the entire specimen.
- Look for signs of liposarcoma: Mainly by firm volumes. Color varies from yellow to white (and firm) depending on the proportion of adipocytic, fibrous and/or myxoid content. Areas of fat necrosis are common in larger lesions. Rarely, infiltrative growth is seen.
- Submit slices from any suspicious parts, or at least one representative slice from the specimen. (A more comprehensive practice is to submit 1 section per centimeter, and 2 sections per cassette.)
- Even absence of hemorrhage or necrosis.
|Mass ((weighing 121 grams)) and measuring 10 x 6,5 x 3,5 cm. ((The surgical margin is intact.)) Cut sections show homogenous yellow color, with no hemorrhage or necrosis. ((The specimen is serially sectioned, and representative sections are submitted for microscopic examination in __ cassettes.))|
See also: General notes on gross processing
An atypical lipomatous tumor (also termed well-differentiated liposarcoma), lipoma-like subtype. At low magnification, the majority of the tumor essentially has the look of benign mature adipocytes (except for mildly increased variation in lipid droplet sizes), but high magnification of a fibrous band shows spindle cells with enlarged, hyperchromatic nuclei. Another clue for liposarcoma is a higher variability of lipid droplet sizes.
Fibrolipoma is a lipoma with focal areas of large amounts of fibrous tissue.
A sclerotic lipoma is one step further: a predominantly fibrous lesion with focal areas of fat.
If unsure of degree of fibrosis: Simply report as lipoma.
Angiolipoma is a lipoma with abundant capillaries, with hyaline or fibrin (pictured) thrombi.
Myxoid liposarcoma: Hypercellular solid sheets of cells lying back to back, with round cells or primitive cytomorphology.
A pedunculated lipomatous skin tumor may be a pedunculated lipofibroma:
For lipomas: (Absence of signs of malignancy.)
((Microscopic description: Tissue composed of univacuolar fat cells and delicate and inconspicuous fibrous septa.))
See also: General notes on reporting
- Monica Dahlgren, Janne Malina, Anna Måsbäck, Otto Ljungberg (1997-02-13). Lilla utskärningen.
- Andreas F Mavrogenis, Panayiotis J Papagelopoulos (2013-02-01). Soft Tissues: Well-differentiated liposarcoma. Atlas of Genetics and Cytogenetics in Oncology and Haematology.
- Pathology Department at NU Hospital Group, Sweden, 2019-2020.
- . Lipoma. Gross Pathology Manual - By The University of Chicago Department of Pathology. Retrieved on 2020-08-26.
- . Lipoma Variant: Fibrolipoma. Stanford University School of Medicine. Retrieved on 2020-02-10.
- Vijay Shankar. Soft tissue - Adipose tissue tumors - Lipoma and variants - Angiolipoma. Pathology Outlines. Topic Completed: 1 August 2012. Minor changes: 20 March 2019
- Michael R. Clay, M.D.. Liposarcoma. PathologyOutlines. Topic Completed: 1 November 2017. Minor changes: 11 May 2021
- Michael R. Clay. Soft tissue - Adipose tissue - Myxoid liposarcoma. PathologyOutlines. Topic Completed: 1 January 2018. Revised: 20 March 2019