View source for Lobular carcinoma in situ

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|author1=[[User:Mikael Häggström|Mikael Häggström]]
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{{Fixation - standard}}
[[File:Histopathology of lobular carcinoma in situ.jpg|thumb|]]
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==Presentations==
*[[Breast biopsy or excision]]
*[[Mastectomy]]
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==Microscopic evaluation==
Lobular carcinoma in situ (LCIS) typically display monomorphic, loosely cohesive, slightly enlarged and evenly spaced cells that fill acini.<ref name=PathologyOutlinesLCIS>{{cite web|url=http://www.pathologyoutlines.com/topic/breastmalignantlcis.html|title=Breast - Noninvasive lobular neoplasia - LCIS classic|author=Sucheta Srivastava}} Topic Completed: 1 September 2017. Minor changes: 21 June 2020</ref>
Cells have indistinct cell borders, pale cytoplasm, and uniform small nuclei with evenly distributed chromatin and inconspicuous nucleoli.<ref name=PathologyOutlinesLCIS/>

===Differential diagnosis===
The main differential diagnosis is '''[[ductal carcinoma in situ]] (DCIS)'''. 
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File:DCIS - Intraductal carcinoma of the breast.jpg|In '''DCIS''', the cells are cohesive and have high grade atypia.<ref>{{cite web|url=https://www.pathologyoutlines.com/topic/breastmalignantlcis.html|title=Breast - Noninvasive lobular neoplasia - LCIS classic (Differential diagnosis section)|author=Sucheta Srivastava, M.D.}} Topic Completed: 1 September 2017. Minor changes: 17 May 2021</ref>
File:Histopathology of DCIS with lobular cancerization.jpg|LCIS typically fills smaller lobules rather than ducts, but '''DCIS can display lobular cancerization''' as shown at bottom of image.{{MH}}
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When unsure, perform immunohistochemistry for E-cadherin and p120:
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File:Immunohistochemistry for E-cadherin in lobular carcinoma in situ.jpg|thumb|'''E-cadherin''' is '''negative''' in '''lobular''' carcinoma in situ (LCIS).
File:Immunohistochemistry for p120 in lobular carcinoma in situ.jpg|'''p120''' has a '''cytoplasmic''' staining in '''lobular''' carcinoma in situ (LCIS).
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In contrast, both E-cadherin (left image below) and p120 (right) have a '''membranous''' staining pattern in [[ductal carcinoma in situ|'''ductal''' carcinoma in situ]] (DCIS).
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Immunohistochemistry for E-cadherin in ductal carcinoma in situ.jpg
Immunohistochemistry for p120 in ductal carcinoma in situ.jpg
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===Biomarkers===
{{Estrogen and progesterone receptors in breast cancers}}
===Microscopic report===
It should contain:<ref>{{cite web|url=https://surgpathcriteria.stanford.edu/breast/lcis/printable.html|title=Lobular Carcinoma in Situ of the Breast|website=Surgical Pathology Criteria|accessdate=2021-12-14}}</ref>
*Type of resection or biopsy, and location
*Results of any supplementary studies performed
*Extent
However, grading and staging is not applicable.
(Margins of excision are not relevant)
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{{Reporting}}
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