Difference between revisions of "Lobular carcinoma in situ"
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File:Immunohistochemistry for p120 in lobular carcinoma in situ.jpg|'''p120''' has a '''cytoplasmic''' staining in '''lobular''' carcinoma in situ. | File:Immunohistochemistry for p120 in lobular carcinoma in situ.jpg|'''p120''' has a '''cytoplasmic''' staining in '''lobular''' carcinoma in situ. | ||
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− | In contrast, both | + | In contrast, both E-cadherin (left image below) and p120 (right) have a '''membranous''' staining pattern in [[ductal carcinoma in situ|'''ductal''' carcinoma in situ]]: |
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Immunohistochemistry for E-cadherin in ductal carcinoma in situ.jpg | Immunohistochemistry for E-cadherin in ductal carcinoma in situ.jpg |
Revision as of 08:44, 16 October 2020
Author:
Mikael Häggström [note 1]
Contents
Fixation
Generally 10% neutral buffered formalin.
Presentations
Microscopic evaluation
Lobular carcinoma in situ (LCIS) typically display monomorphic, loosely cohesive, slightly enlarged and evenly spaced cells that fill acini.[1] Cells have indistinct cell borders, pale cytoplasm, and uniform small nuclei with evenly distributed chromatin and inconspicuous nucleoli.[1]
When unsure, perform immunohistochemistry for E-cadherin and p120:
In contrast, both E-cadherin (left image below) and p120 (right) have a membranous staining pattern in ductal carcinoma in situ:
Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ 1.0 1.1 Sucheta Srivastava. Breast - Noninvasive lobular neoplasia - LCIS classic. Topic Completed: 1 September 2017. Minor changes: 21 June 2020
Image sources