Difference between revisions of "Lobular carcinoma in situ"
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Cells have indistinct cell borders, pale cytoplasm, and uniform small nuclei with evenly distributed chromatin and inconspicuous nucleoli.<ref name=PathologyOutlinesLCIS/> | Cells have indistinct cell borders, pale cytoplasm, and uniform small nuclei with evenly distributed chromatin and inconspicuous nucleoli.<ref name=PathologyOutlinesLCIS/> | ||
| − | When unsure, perform immunohistochemistry for E-cadherin and p120: | + | ===Differential diagnosis=== |
| + | The main differential diagnosis is [[ductal carcinoma in situ]]. When unsure, perform immunohistochemistry for E-cadherin and p120: | ||
<gallery mode=packed> | <gallery mode=packed> | ||
File:Immunohistochemistry for E-cadherin in lobular carcinoma in situ.jpg|thumb|'''E-cadherin''' is '''negative''' in '''lobular''' carcinoma in situ. | File:Immunohistochemistry for E-cadherin in lobular carcinoma in situ.jpg|thumb|'''E-cadherin''' is '''negative''' in '''lobular''' carcinoma in situ. | ||
Revision as of 10:30, 17 November 2020
Author:
Mikael Häggström [note 1]
Contents
Fixation
Generally 10% neutral buffered formalin.
Presentations
Microscopic evaluation
Lobular carcinoma in situ (LCIS) typically display monomorphic, loosely cohesive, slightly enlarged and evenly spaced cells that fill acini.[1] Cells have indistinct cell borders, pale cytoplasm, and uniform small nuclei with evenly distributed chromatin and inconspicuous nucleoli.[1]
Differential diagnosis
The main differential diagnosis is ductal carcinoma in situ. When unsure, perform immunohistochemistry for E-cadherin and p120:
E-cadherin is negative in lobular carcinoma in situ.
p120 has a cytoplasmic staining in lobular carcinoma in situ.
In contrast, both E-cadherin (left image below) and p120 (right) have a membranous staining pattern in ductal carcinoma in situ:
Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ 1.0 1.1 Sucheta Srivastava. Breast - Noninvasive lobular neoplasia - LCIS classic. Topic Completed: 1 September 2017. Minor changes: 21 June 2020
Image sources
