Difference between revisions of "Lobular carcinoma in situ"
(Microscopic report) |
(→Microscopic report: Corrected) |
||
Line 30: | Line 30: | ||
</gallery> | </gallery> | ||
===Microscopic report=== | ===Microscopic report=== | ||
− | {{ | + | It should contain:<ref>{{cite web|url=https://surgpathcriteria.stanford.edu/breast/lcis/printable.html|title=Lobular Carcinoma in Situ of the Breast|website=Surgical Pathology Criteria|accessdate=2021-12-14}}</ref> |
+ | *Type of resection or biopsy, and location | ||
+ | *Results of any supplementary studies performed | ||
+ | *Extent | ||
+ | However, grading and staging is not applicable. | ||
+ | (Margins of excision are not relevant) | ||
+ | |||
{{Reporting}} | {{Reporting}} | ||
{{Bottom}} | {{Bottom}} |
Revision as of 21:12, 14 December 2021
Author:
Mikael Häggström [note 1]
Contents
Fixation
Generally 10% neutral buffered formalin.
Presentations
Microscopic evaluation
Lobular carcinoma in situ (LCIS) typically display monomorphic, loosely cohesive, slightly enlarged and evenly spaced cells that fill acini.[1] Cells have indistinct cell borders, pale cytoplasm, and uniform small nuclei with evenly distributed chromatin and inconspicuous nucleoli.[1]
Differential diagnosis
The main differential diagnosis is ductal carcinoma in situ (DCIS).
In DCIS, the cells are cohesive and have high grade atypia.[2]
LCIS typically fills smaller lobules rather than ducts, but DCIS can display lobular cancerization as shown at bottom of image.[image 1]
When unsure, perform immunohistochemistry for E-cadherin and p120:
In contrast, both E-cadherin (left image below) and p120 (right) have a membranous staining pattern in ductal carcinoma in situ (DCIS).
Microscopic report
It should contain:[3]
- Type of resection or biopsy, and location
- Results of any supplementary studies performed
- Extent
However, grading and staging is not applicable. (Margins of excision are not relevant)
See also: General notes on reporting
Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ 1.0 1.1 Sucheta Srivastava. Breast - Noninvasive lobular neoplasia - LCIS classic. Topic Completed: 1 September 2017. Minor changes: 21 June 2020
- ↑ Sucheta Srivastava, M.D.. Breast - Noninvasive lobular neoplasia - LCIS classic (Differential diagnosis section). Topic Completed: 1 September 2017. Minor changes: 17 May 2021
- ↑ . Lobular Carcinoma in Situ of the Breast. Surgical Pathology Criteria. Retrieved on 2021-12-14.
Image sources
- ↑ Image(s) by: Mikael Häggström, M.D. Public Domain
- Author info
- Reusing images