Difference between revisions of "Lobular carcinoma in situ"
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The main differential diagnosis is '''[[ductal carcinoma in situ]] (DCIS)'''. | The main differential diagnosis is '''[[ductal carcinoma in situ]] (DCIS)'''. | ||
<gallery mode=packed heights=190> | <gallery mode=packed heights=190> | ||
| − | File:DCIS - Intraductal carcinoma of the breast.jpg|In '''DCIS''', the cells are cohesive and have high grade atypia.< | + | File:DCIS - Intraductal carcinoma of the breast.jpg|In '''DCIS''', the cells are cohesive and have high grade atypia.<ref>{{cite web|url=https://www.pathologyoutlines.com/topic/breastmalignantlcis.html|title=Breast - Noninvasive lobular neoplasia - LCIS classic (Differential diagnosis section)|author=Sucheta Srivastava, M.D.}} Topic Completed: 1 September 2017. Minor changes: 17 May 2021</ref> |
File:Histopathology of DCIS with lobular cancerization.jpg|LCIS typically fills smaller lobules rather than ducts, but '''DCIS can display lobular cancerization''' as shown at bottom of image.{{MH}} | File:Histopathology of DCIS with lobular cancerization.jpg|LCIS typically fills smaller lobules rather than ducts, but '''DCIS can display lobular cancerization''' as shown at bottom of image.{{MH}} | ||
</gallery> | </gallery> | ||
Revision as of 18:59, 2 August 2021
Author:
Mikael Häggström [note 1]
Contents
Fixation
Generally 10% neutral buffered formalin.
Presentations
Microscopic evaluation
Lobular carcinoma in situ (LCIS) typically display monomorphic, loosely cohesive, slightly enlarged and evenly spaced cells that fill acini.[1] Cells have indistinct cell borders, pale cytoplasm, and uniform small nuclei with evenly distributed chromatin and inconspicuous nucleoli.[1]
Differential diagnosis
The main differential diagnosis is ductal carcinoma in situ (DCIS).
In DCIS, the cells are cohesive and have high grade atypia.[2]
LCIS typically fills smaller lobules rather than ducts, but DCIS can display lobular cancerization as shown at bottom of image.[image 1]
When unsure, perform immunohistochemistry for E-cadherin and p120:
E-cadherin is negative in lobular carcinoma in situ (LCIS).
p120 has a cytoplasmic staining in lobular carcinoma in situ (LCIS).
In contrast, both E-cadherin (left image below) and p120 (right) have a membranous staining pattern in ductal carcinoma in situ (DCIS).
Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ 1.0 1.1 Sucheta Srivastava. Breast - Noninvasive lobular neoplasia - LCIS classic. Topic Completed: 1 September 2017. Minor changes: 21 June 2020
- ↑ Sucheta Srivastava, M.D.. Breast - Noninvasive lobular neoplasia - LCIS classic (Differential diagnosis section). Topic Completed: 1 September 2017. Minor changes: 17 May 2021
Image sources
- ↑ Image(s) by: Mikael Häggström, M.D. Public Domain
- Author info
- Reusing images
