Lobular carcinoma in situ

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Revision as of 20:48, 14 December 2021 by Mikael Häggström (talk | contribs) (Microscopic report)
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Author: Mikael Häggström [note 1]

Fixation

Generally 10% neutral buffered formalin.

Histopathology of lobular carcinoma in situ.jpg

Presentations

Microscopic evaluation

Lobular carcinoma in situ (LCIS) typically display monomorphic, loosely cohesive, slightly enlarged and evenly spaced cells that fill acini.[1] Cells have indistinct cell borders, pale cytoplasm, and uniform small nuclei with evenly distributed chromatin and inconspicuous nucleoli.[1]

Differential diagnosis

The main differential diagnosis is ductal carcinoma in situ (DCIS).

When unsure, perform immunohistochemistry for E-cadherin and p120:

In contrast, both E-cadherin (left image below) and p120 (right) have a membranous staining pattern in ductal carcinoma in situ (DCIS).

Microscopic report

For cancers, generally include a synoptic report, such as per College of American Pathologists (CAP) protocols at cap.org/protocols-and-guidelines.

  See also: General notes on reporting


Notes

  1. For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.

Main page

References

  1. 1.0 1.1 Sucheta Srivastava. Breast - Noninvasive lobular neoplasia - LCIS classic. Topic Completed: 1 September 2017. Minor changes: 21 June 2020
  2. Sucheta Srivastava, M.D.. Breast - Noninvasive lobular neoplasia - LCIS classic (Differential diagnosis section). Topic Completed: 1 September 2017. Minor changes: 17 May 2021

Image sources