Lobular carcinoma in situ

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Author: Mikael Häggström [note 1]


Generally 10% neutral buffered formalin.

Histopathology of lobular carcinoma in situ.jpg


Microscopic evaluation

Lobular carcinoma in situ (LCIS) typically display monomorphic, loosely cohesive, slightly enlarged and evenly spaced cells that fill acini.[1] Cells have indistinct cell borders, pale cytoplasm, and uniform small nuclei with evenly distributed chromatin and inconspicuous nucleoli.[1]

Differential diagnosis

The main differential diagnosis is ductal carcinoma in situ (DCIS).

When unsure, perform immunohistochemistry for E-cadherin and p120:

In contrast, both E-cadherin (left image below) and p120 (right) have a membranous staining pattern in ductal carcinoma in situ (DCIS).


Generally perform immunohistochemistry for estrogen and progesterone receptors and calculate the percentage of positive tumor cells.

Microscopic report

It should contain:[3]

  • Type of resection or biopsy, and location
  • Results of any supplementary studies performed
  • Extent

However, grading and staging is not applicable. (Margins of excision are not relevant)

  See also: General notes on reporting


  1. For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.

Main page


  1. 1.0 1.1 Sucheta Srivastava. Breast - Noninvasive lobular neoplasia - LCIS classic. Topic Completed: 1 September 2017. Minor changes: 21 June 2020
  2. Sucheta Srivastava, M.D.. Breast - Noninvasive lobular neoplasia - LCIS classic (Differential diagnosis section). Topic Completed: 1 September 2017. Minor changes: 17 May 2021
  3. . Lobular Carcinoma in Situ of the Breast. Surgical Pathology Criteria. Retrieved on 2021-12-14.

Image sources