Lung adenocarcinoma
Author:
Mikael Häggström [note 1]
Contents
Presentation
Microscopic examination
Invasiveness
- An adenocarcinoma in situ is defined as a tumour of ≤ 3 cm with pure lepidic pattern but no lymphatic, vascular or pleural invasion and no tumor necrosis.[1]
- Minimally invasive adenocarcinoma: a small (≤3 cm), solitary tumour with predominant alveolar epithelial appearance (lepidic growth), as in situ adenocarcinoma of the lung, with a zone of focal invasion of the stroma with a size inferior to 5 mm.[1] It has no lymphatic, vascular or pleural invasion and no tumor necrosis.
- Invasive adenocarcinoma: Tumor of larger size or focus of invasion, or with lymphatic, vascular, pleural invasion or tumor necrosis.
Predominant pattern
For invasive adenocarcinomas, generally specify the pattern (mainly lepidic, acinar, papillary, micropapillary, solid predominant or "predominant subtype cannot be determined).
Lung adenocarcinoma, with lepidic pattern shown, wherein tumors cells cover alveolar walls.
Lung adenocarcinoma, with solid pattern.
Degree of differentiation
Lung adenocarcinomas may be classified as follows:[2]
| Well differentiated | Solid pattern< 90% and mild/moderate atypia |
| |
| Poorly differentiated | Solid pattern ≥ 90% and severe atypia |
Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ 1.0 1.1 Lambe, Gerard; Durand, Michael; Buckley, Anne; Nicholson, Siobhan; McDermott, Ronan (2020). "Adenocarcinoma of the lung: from BAC to the future ". Insights into Imaging 11 (1). doi:. ISSN 1869-4101.
- ↑ Barletta, Justine A.; Yeap, Beow Y.; Chirieac, Lucian R. (2010). "Prognostic significance of grading in lung adenocarcinoma ". Cancer 116 (3): 659–669. doi:. ISSN 0008543X.
Image sources
