Difference between revisions of "Ovarian tumor"

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!rowspan=3| [[Germ cell tumor]] !! Mature cystic [[teratoma]]
 
!rowspan=3| [[Germ cell tumor]] !! Mature cystic [[teratoma]]
| 46,0% || 0,17% to 2%<ref name="MandalBadhe2012">{{cite journal|last1=Mandal|first1=Shramana|last2=Badhe|first2=Bhawana A.|title=Malignant Transformation in a Mature Teratoma with Metastatic Deposits in the Omentum: A Case Report|journal=Case Reports in Pathology|volume=2012|year=2012|pages=1–3|issn=2090-6781|doi=10.1155/2012/568062}}</ref> || Cystic, with elements of all 3 [[germ layer]]s ([[endoderm]], [[mesoderm]] and [[ectoderm]]).<ref>{{cite web|url=https://www.pathologyoutlines.com/topic/skintumornonmelanocyticbenigncysticteratoma.html|title=Skin nonmelanocytic tumor - Other tumors of skin - Benign (mature) cystic teratoma|author=Hillary Rose Elwood|website=pathology Outlines}} Topic Completed: 1 November 2016. Revised: 4 April 2019</ref> || [[File:Mature Cystic Teratoma of the Ovary Hair Follicles (4047144010).jpg|thumb|190px|Hair follicles.]]
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| 46,0% || 0.17% to 2%<ref name="MandalBadhe2012">{{cite journal|last1=Mandal|first1=Shramana|last2=Badhe|first2=Bhawana A.|title=Malignant Transformation in a Mature Teratoma with Metastatic Deposits in the Omentum: A Case Report|journal=Case Reports in Pathology|volume=2012|year=2012|pages=1–3|issn=2090-6781|doi=10.1155/2012/568062}}</ref> || Cystic, with elements of all 3 [[germ layer]]s ([[endoderm]], [[mesoderm]] and [[ectoderm]]).<ref>{{cite web|url=https://www.pathologyoutlines.com/topic/skintumornonmelanocyticbenigncysticteratoma.html|title=Skin nonmelanocytic tumor - Other tumors of skin - Benign (mature) cystic teratoma|author=Hillary Rose Elwood|website=pathology Outlines}} Topic Completed: 1 November 2016. Revised: 4 April 2019</ref> || [[File:Mature Cystic Teratoma of the Ovary Hair Follicles (4047144010).jpg|thumb|190px|Hair follicles.]]
 
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! [[Immature teratoma]]  
 
! [[Immature teratoma]]  
| 2,5% || 100,0% || A [[teratoma]] that contains [[anaplastic]] immature elements, and is often synonymous with ''malignant teratoma''.<ref name="SunDing2019">{{cite journal|last1=Sun|first1=Hang|last2=Ding|first2=Hongxin|last3=Wang|first3=Jianjun|last4=Zhang|first4=Emma|last5=Fang|first5=Yihua|last6=Li|first6=Zhenhua|last7=Yu|first7=Xiao|last8=Wang|first8=Chongren|last9=Zhao|first9=Yifan|last10=Chen|first10=Kan|last11=Wen|first11=Siwan|last12=Li|first12=Liang|last13=Shan|first13=Shan|last14=Hong|first14=Liu|last15=Chen|first15=Face|last16=Su|first16=Pu|title=The differences between gonadal and extra-gonadal malignant teratomas in both genders and the effects of chemotherapy|journal=BMC Cancer|volume=19|issue=1|year=2019|issn=1471-2407|doi=10.1186/s12885-019-5598-0}}</ref> || [[File:Histopathology of immature teratoma of the ovary.jpg|200px]]
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| 2,5% || 100% || A [[teratoma]] that contains [[anaplastic]] immature elements, and is often synonymous with ''malignant teratoma''.<ref name="SunDing2019">{{cite journal|last1=Sun|first1=Hang|last2=Ding|first2=Hongxin|last3=Wang|first3=Jianjun|last4=Zhang|first4=Emma|last5=Fang|first5=Yihua|last6=Li|first6=Zhenhua|last7=Yu|first7=Xiao|last8=Wang|first8=Chongren|last9=Zhao|first9=Yifan|last10=Chen|first10=Kan|last11=Wen|first11=Siwan|last12=Li|first12=Liang|last13=Shan|first13=Shan|last14=Hong|first14=Liu|last15=Chen|first15=Face|last16=Su|first16=Pu|title=The differences between gonadal and extra-gonadal malignant teratomas in both genders and the effects of chemotherapy|journal=BMC Cancer|volume=19|issue=1|year=2019|issn=1471-2407|doi=10.1186/s12885-019-5598-0}}</ref> || [[File:Histopathology of immature teratoma of the ovary.jpg|200px]]
 
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! Other germ cell tumors  
 
! Other germ cell tumors  
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!rowspan=4| [[Surface epithelial-stromal tumor]] !! Serous tumor   
 
!rowspan=4| [[Surface epithelial-stromal tumor]] !! Serous tumor   
| 25,3% || 18,5% || Benign serous tumors of the right ovarian cyst are thinwalled unilocular cysts that are lined by ciliated pseudostratified cuboidal or columnar epithelium.<ref name="BaradwanAlalyani2018">{{cite journal|last1=Baradwan|first1=Saeed|last2=Alalyani|first2=Haneen|last3=Baradwan|first3=Amira|last4=Baradwan|first4=Afnan|last5=Al-Ghamdi|first5=Maram|last6=Alnemari|first6=Jameel|last7=Al-Jaroudi|first7=Dania|title=Bilateral ovarian masses with different histopathology in each ovary|journal=Clinical Case Reports|volume=6|issue=5|year=2018|pages=784–787|issn=20500904|doi=10.1002/ccr3.1466}}</ref> || [[File:Histopathology of lining of a benign serous tumor of the ovary.jpg|200px]]
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| 25,3% || 18.5% || Benign serous tumors of the right ovarian cyst are thinwalled unilocular cysts that are lined by ciliated pseudostratified cuboidal or columnar epithelium.<ref name="BaradwanAlalyani2018">{{cite journal|last1=Baradwan|first1=Saeed|last2=Alalyani|first2=Haneen|last3=Baradwan|first3=Amira|last4=Baradwan|first4=Afnan|last5=Al-Ghamdi|first5=Maram|last6=Alnemari|first6=Jameel|last7=Al-Jaroudi|first7=Dania|title=Bilateral ovarian masses with different histopathology in each ovary|journal=Clinical Case Reports|volume=6|issue=5|year=2018|pages=784–787|issn=20500904|doi=10.1002/ccr3.1466}}</ref> || [[File:Histopathology of lining of a benign serous tumor of the ovary.jpg|200px]]
 
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! Mucinous tumor
 
! Mucinous tumor
| 15,7% || 8,8% || Benign mucinous tumors of the ovary consist of simple, nonstratified columnar epithelium with basally-located hyperchromatic nuclei and resemble gastric foveolar epithelium.<ref name="BaradwanAlalyani2018"/> || [[File:Histopathology of lining of a benign mucinous tumor of the ovary.jpg|200px]]
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| 15,7% || 8.8% || Benign mucinous tumors of the ovary consist of simple, nonstratified columnar epithelium with basally-located hyperchromatic nuclei and resemble gastric foveolar epithelium.<ref name="BaradwanAlalyani2018"/> || [[File:Histopathology of lining of a benign mucinous tumor of the ovary.jpg|200px]]
 
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! [[Endometrioid tumor]]  
 
! [[Endometrioid tumor]]  
| 1,1% || 100,0%  || Tubular glands, resembling endometrium.<ref>{{cite web|url=https://www.pathologyoutlines.com/topic/ovarytumorendometrioid.html|title=Ovary tumor - Endometrioid tumors - General|author=Shahrzad Ehdaivand|website=Pathology Outlines}} Topic Completed: 1 December 2012. Revised: 6 March 2020</ref> || [[File:Histopathology of well-differentiated endometrioid adenocarcinoma.png|200px]]
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| 1,1% || Almost 100%  || Tubular glands, resembling endometrium.<ref>{{cite web|url=https://www.pathologyoutlines.com/topic/ovarytumorendometrioid.html|title=Ovary tumor - Endometrioid tumors - General|author=Shahrzad Ehdaivand|website=Pathology Outlines}} Topic Completed: 1 December 2012. Revised: 6 March 2020</ref> || [[File:Histopathology of well-differentiated endometrioid adenocarcinoma.png|200px]]
 
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! Other surface-epithelial tumors  
 
! Other surface-epithelial tumors  
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!rowspan=3| [[Sex cord-stromal tumor]] !! [[Ovarian fibroma]]   
 
!rowspan=3| [[Sex cord-stromal tumor]] !! [[Ovarian fibroma]]   
| 1,4% || 0,0%  || [[Spindle-shape]]d fibroblastic cells and abundant collagen.<ref name="ParwatePatel2015">{{cite journal|last1=Parwate|first1=Nikhil Sadanand|last2=Patel|first2=Shilpa M.|last3=Arora|first3=Ruchi|last4=Gupta|first4=Monisha|title=Ovarian Fibroma: A Clinico-pathological Study of 23 Cases with Review of Literature|journal=The Journal of Obstetrics and Gynecology of India|volume=66|issue=6|year=2015|pages=460–465|issn=0971-9202|doi=10.1007/s13224-015-0717-6}}</ref> || [[File:Histopathology of an ovarian fibroma.jpg|200px]]
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| 1,4% || 0%  || [[Spindle-shape]]d fibroblastic cells and abundant collagen.<ref name="ParwatePatel2015">{{cite journal|last1=Parwate|first1=Nikhil Sadanand|last2=Patel|first2=Shilpa M.|last3=Arora|first3=Ruchi|last4=Gupta|first4=Monisha|title=Ovarian Fibroma: A Clinico-pathological Study of 23 Cases with Review of Literature|journal=The Journal of Obstetrics and Gynecology of India|volume=66|issue=6|year=2015|pages=460–465|issn=0971-9202|doi=10.1007/s13224-015-0717-6}}</ref> || [[File:Histopathology of an ovarian fibroma.jpg|200px]]
 
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! Adult [[Granulosa cell tumour|granulosa cell tumor]]  
 
! Adult [[Granulosa cell tumour|granulosa cell tumor]]  
| 1,1% || 100,0%  || Small, bland, cuboidal to polygonal cells in various patterns.<ref>{{cite web|url=http://www.pathologyoutlines.com/topic/ovarytumorgctadult.html|title=Ovary tumor - Sex cord stromal tumors - Granulosa cell tumor - adult|author=Shahrzad Ehdaivand|website=Pathology Outlines}} Topic Completed: 1 December 2012. Revised: 9 March 2020</ref> || [[File:Granulosa Cell Tumor of the Ovary (5621714007).jpg|200px]]
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| 1,1% || Almost 100%  || Small, bland, cuboidal to polygonal cells in various patterns.<ref>{{cite web|url=http://www.pathologyoutlines.com/topic/ovarytumorgctadult.html|title=Ovary tumor - Sex cord stromal tumors - Granulosa cell tumor - adult|author=Shahrzad Ehdaivand|website=Pathology Outlines}} Topic Completed: 1 December 2012. Revised: 9 March 2020</ref> || [[File:Granulosa Cell Tumor of the Ovary (5621714007).jpg|200px]]
 
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! Other sex cord-stromal tumors  
 
! Other sex cord-stromal tumors  
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!colspan=2| Secondary/metastatic) tumor  
 
!colspan=2| Secondary/metastatic) tumor  
| 1,7% || 100,0%  || Usually from [[breast cancer]], [[colon cancer]], [[endometrial cancer]], [[stomach cancer]] or [[cervical cancer]].<ref name=Lee-Jones>{{cite web|url=http://atlasgeneticsoncology.org/Tumors/OvarianTumOverviewID5231.html|title=Ovarian tumours : an overview|author=Lisa Lee-Jones, University of Wales College of Medicine|date=2003-12-01|website=Atlas of Genetics and Cytogenetics in Oncology and Haematology}}</ref>
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| 1,7% || 100%  || Usually from [[breast cancer]], [[colon cancer]], [[endometrial cancer]], [[stomach cancer]] or [[cervical cancer]].<ref name=Lee-Jones>{{cite web|url=http://atlasgeneticsoncology.org/Tumors/OvarianTumOverviewID5231.html|title=Ovarian tumours : an overview|author=Lisa Lee-Jones, University of Wales College of Medicine|date=2003-12-01|website=Atlas of Genetics and Cytogenetics in Oncology and Haematology}}</ref>
 
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Revision as of 09:24, 17 March 2020

Author: Mikael Häggström [note 1]

Microscopic evaluation

Ovarian tumors by incidence and risk of ovarian cancer[1]

Look for the most common types of ovarian tumor:

Type Subtype Relative incidence[2] Percent malignant[2] Comments Micrograph
Germ cell tumor Mature cystic teratoma 46,0% 0.17% to 2%[3] Cystic, with elements of all 3 germ layers (endoderm, mesoderm and ectoderm).[4]
Hair follicles.
Immature teratoma 2,5% 100% A teratoma that contains anaplastic immature elements, and is often synonymous with malignant teratoma.[5] Histopathology of immature teratoma of the ovary.jpg
Other germ cell tumors 3,0% Others mainly include dysgerminoma, yolk sac tumor, struma ovarii and squamous cell carcinoma arising from a dermoid cyst, and malignant mixed germ cell tumor.[2]
Surface epithelial-stromal tumor Serous tumor 25,3% 18.5% Benign serous tumors of the right ovarian cyst are thinwalled unilocular cysts that are lined by ciliated pseudostratified cuboidal or columnar epithelium.[6] Histopathology of lining of a benign serous tumor of the ovary.jpg
Mucinous tumor 15,7% 8.8% Benign mucinous tumors of the ovary consist of simple, nonstratified columnar epithelium with basally-located hyperchromatic nuclei and resemble gastric foveolar epithelium.[6] Histopathology of lining of a benign mucinous tumor of the ovary.jpg
Endometrioid tumor 1,1% Almost 100% Tubular glands, resembling endometrium.[7] Histopathology of well-differentiated endometrioid adenocarcinoma.png
Other surface-epithelial tumors 1,4% Others include mainly malignant mixed mullerian tumor, Brenner tumor and mixed epithelial tumor.[2]
Sex cord-stromal tumor Ovarian fibroma 1,4% 0% Spindle-shaped fibroblastic cells and abundant collagen.[8] Histopathology of an ovarian fibroma.jpg
Adult granulosa cell tumor 1,1% Almost 100% Small, bland, cuboidal to polygonal cells in various patterns.[9] Granulosa Cell Tumor of the Ovary (5621714007).jpg
Other sex cord-stromal tumors 0,8% Others include mainly juvenile granulosa cell tumor, thecoma and sclerosing stromal tumor[2]
Secondary/metastatic) tumor 1,7% 100% Usually from breast cancer, colon cancer, endometrial cancer, stomach cancer or cervical cancer.[10]

Notes

  1. For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.

Main page

References

  1. - Vaidya, SA; Kc, S; Sharma, P; Vaidya, S (2014). "Spectrum of ovarian tumors in a referral hospital in Nepal ". Journal of Pathology of Nepal 4 (7): 539–543. doi:10.3126/jpn.v4i7.10295. ISSN 2091-0908. 
    - Minor adjustment for mature cystic teratomas (0.17 to 2% risk of ovarian cancer): Mandal, Shramana; Badhe, Bhawana A. (2012). "Malignant Transformation in a Mature Teratoma with Metastatic Deposits in the Omentum: A Case Report ". Case Reports in Pathology 2012: 1–3. doi:10.1155/2012/568062. ISSN 2090-6781. 
  2. 2.0 2.1 2.2 2.3 2.4 Unless otherwise specified in boxes, reference is: Vaidya, SA; Kc, S; Sharma, P; Vaidya, S (2014). "Spectrum of ovarian tumors in a referral hospital in Nepal ". Journal of Pathology of Nepal 4 (7): 539–543. doi:10.3126/jpn.v4i7.10295. ISSN 2091-0908. 
  3. Mandal, Shramana; Badhe, Bhawana A. (2012). "Malignant Transformation in a Mature Teratoma with Metastatic Deposits in the Omentum: A Case Report ". Case Reports in Pathology 2012: 1–3. doi:10.1155/2012/568062. ISSN 2090-6781. 
  4. Hillary Rose Elwood. Skin nonmelanocytic tumor - Other tumors of skin - Benign (mature) cystic teratoma. pathology Outlines. Topic Completed: 1 November 2016. Revised: 4 April 2019
  5. Sun, Hang; Ding, Hongxin; Wang, Jianjun; Zhang, Emma; Fang, Yihua; Li, Zhenhua; Yu, Xiao; Wang, Chongren; et al. (2019). "The differences between gonadal and extra-gonadal malignant teratomas in both genders and the effects of chemotherapy ". BMC Cancer 19 (1). doi:10.1186/s12885-019-5598-0. ISSN 1471-2407. 
  6. 6.0 6.1 Baradwan, Saeed; Alalyani, Haneen; Baradwan, Amira; Baradwan, Afnan; Al-Ghamdi, Maram; Alnemari, Jameel; Al-Jaroudi, Dania (2018). "Bilateral ovarian masses with different histopathology in each ovary ". Clinical Case Reports 6 (5): 784–787. doi:10.1002/ccr3.1466. ISSN 20500904. 
  7. Shahrzad Ehdaivand. Ovary tumor - Endometrioid tumors - General. Pathology Outlines. Topic Completed: 1 December 2012. Revised: 6 March 2020
  8. Parwate, Nikhil Sadanand; Patel, Shilpa M.; Arora, Ruchi; Gupta, Monisha (2015). "Ovarian Fibroma: A Clinico-pathological Study of 23 Cases with Review of Literature ". The Journal of Obstetrics and Gynecology of India 66 (6): 460–465. doi:10.1007/s13224-015-0717-6. ISSN 0971-9202. 
  9. Shahrzad Ehdaivand. Ovary tumor - Sex cord stromal tumors - Granulosa cell tumor - adult. Pathology Outlines. Topic Completed: 1 December 2012. Revised: 9 March 2020
  10. Lisa Lee-Jones, University of Wales College of Medicine (2003-12-01). Ovarian tumours : an overview. Atlas of Genetics and Cytogenetics in Oncology and Haematology.

Image sources