Pancreatic tumor

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Author: Mikael Häggström [note 1]

Microscopic evaluation

Cancer type Relative incidence[2] Microscopy findings[2] Micrograph Immunohistochemistry markers[2] Genetic alterations[2]
Pancreatic ductal adenocarcinoma (PDAC) 90% Glands and desmoplasia Histopathology of pancreatic ductal adenocarcinoma.jpg
Pancreatic acinar cell carcinoma (ACC) 1% to 2% Granular appearance Histopathology of acinar cell carcinoma of the pancreas.jpg
Adenosquamous carcinoma 1% to 4%[3] Combination of gland-like cells and squamous epithelial cells. Histopathology of adenosquamous carcinoma of the pancreas.jpg Positive for:

Negative for:

Pancreatic neuroendocrine tumor 5% Multiple nests of tumor cells
Gastrinoma.jpg
Gastrinoma
Pre-cancer below for comparison:
Precancer:
Intraductal papillary mucinous neoplasm (IPMN)
3% Mucinous epithelial cells.[4] Growth within the pancreatic ducts.[5] Histopathology of pancreatobiliary intraductal papillary mucinous neoplasm in the pancreas.jpg

Further information: Evaluation of tumors

Notes

  1. For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.

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References

  1. Hackeng WM, Hruban RH, Offerhaus GJ, Brosens LA (2016). "Surgical and molecular pathology of pancreatic neoplasms. ". Diagn Pathol 11 (1): 47. doi:10.1186/s13000-016-0497-z. PMID 27267993. PMC: 4897815. Archived from the original. . 
    - "This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/)"
    - Image title and optimization: Mikael Häggström, M.D.
  2. 2.0 2.1 2.2 2.3 Unless otherwise specified in boxes, reference is: "Therapeutic Implications of Molecular Subtyping for Pancreatic Cancer ". Oncology 31 (3): 159–66, 168. March 2017. PMID 28299752. Archived from the original. . 
  3. "Adenosquamous carcinoma of the pancreas: a case report ". Cases Journal 3 (1): 41. February 2010. doi:10.1186/1757-1626-3-41. PMID 20205828. 
  4. Diana Agostini-Vulaj. Pancreas – Exocrine tumors / carcinomas – Intraductal papillary mucinous neoplasm (IPMN). Pathology Outlines. Topic Completed: 1 July 2018. Revised: 9 March 2020
  5. "Pathologic Evaluation and Reporting of Intraductal Papillary Mucinous Neoplasms of the Pancreas and Other Tumoral Intraepithelial Neoplasms of Pancreatobiliary Tract: Recommendations of Verona Consensus Meeting ". Annals of Surgery 263 (1): 162–77. January 2016. doi:10.1097/SLA.0000000000001173. PMID 25775066. 

Image sources