Parathyroid glands
Author:
Mikael Häggström [note 1]
Contents
Autopsy
Optionally for a comprehensive autopsy, or where there is suspicion of parathyroid pathology, an effort is made to find the parathyroid glands, and inspect them for general or focal hyper-/neoplasia.
Microscopic evaluation
Look for the main findings, which are:
- Hyperplastic glands, often nodular and asymmetric on inspection, and microscopy frequently show increased number of oxyphil cells.[1]
- Parathyroid adenoma.[1]
Serum calcium levels are generally elevated in patients with adenomas or hyperplastic glands containing large nodules, and often correlates with nephrosclerosis.[1]
Location and histology of the parathyroid glands
Parathyroid chief cell hyperplasia: An increase in the parenchymal cell mass,as a result of the proliferation of chief cells, oncocytes, and transitional oncocytes in multiple parathyroid glands.[2]
Parathyroid adenoma, histology
Parathyroid adenoma, fine needle aspiration
Parathyroid venous congestion in circulatory failure.
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Microscopy report
Normal example:
- Sections show <<1, 2, 3, 4>> parathyroid glands with no signs of hyperplasia or tumor.
See also
Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ 1.0 1.1 1.2 Åkerström, G.; Rudberg, C.; Grimelius, L.; Bergström, R.; Johansson, H.; Ljunghall, S.; Rastad, J. (1986). "Histologic parathyroid abnormalities in an autopsy series ". Human Pathology 17 (5): 520–527. doi:. ISSN 00468177.
- ↑ Piciucchi, Sara; Barone, Domenico; Gavelli, Giampaolo; Dubini, Alessandra; Oboldi, Devil; Matteuci, Federica (2012). "Primary Hyperparathyroidism: Imaging to Pathology
". Journal of Clinical Imaging Science 2: 59. doi:. ISSN 2156-7514.
- This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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