Optionally for a comprehensive autopsy, or where there is suspicion of parathyroid pathology, an effort is made to find the parathyroid glands, and inspect them for general or focal hyper-/neoplasia.
Look for the most common significant findings, which are:
- Hyperplastic glands, often nodular and asymmetric on inspection, and microscopy frequently show increased number of oxyphil cells.
- Parathyroid adenoma.
Serum calcium levels are generally elevated in patients with adenomas or hyperplastic glands containing large nodules, and often correlates with nephrosclerosis.
Parathyroid chief cell hyperplasia: An increase in the parenchymal cell mass,as a result of the proliferation of chief cells, oncocytes, and transitional oncocytes in multiple parathyroid glands.
- Sections show <<1, 2, 3, 4>> parathyroid glands with no focal changes or signs of hyperplasia.
- Åkerström, G.; Rudberg, C.; Grimelius, L.; Bergström, R.; Johansson, H.; Ljunghall, S.; Rastad, J. (1986). "Histologic parathyroid abnormalities in an autopsy series ". Human Pathology 17 (5): 520–527. doi:10.1016/S0046-8177(86)80043-0. ISSN 00468177.
- Piciucchi, Sara; Barone, Domenico; Gavelli, Giampaolo; Dubini, Alessandra; Oboldi, Devil; Matteuci, Federica (2012). "Primary Hyperparathyroidism: Imaging to Pathology
". Journal of Clinical Imaging Science 2: 59. doi:10.4103/2156-7514.102053. ISSN 2156-7514.
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