Necessary components are:
- Weight of the parathyroid gland or fragment thereof. For reference, 90% of normal parathyroid glands weight less than 100g, and 96% less than 160g.
- Presence of parathyroid tissue upon frozen section.
Optionally for a comprehensive autopsy, or where there is suspicion of parathyroid pathology, an effort is made to find the parathyroid glands, and inspect them for general or focal hyper-/neoplasia.
Look for the most common significant findings, which are:
- Hyperplastic glands, often nodular and asymmetric on inspection, and microscopy frequently show increased number of oxyphil cells.
- Parathyroid adenoma.
Serum calcium levels are generally elevated in patients with adenomas or hyperplastic glands containing large nodules, and often correlates with nephrosclerosis.
Parathyroid chief cell hyperplasia: An increase in the parenchymal cell mass,as a result of the proliferation of chief cells, oncocytes, and transitional oncocytes in multiple parathyroid glands.
- Sections show <<1, 2, 3, 4>> parathyroid glands with no focal changes or signs of hyperplasia.
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- Piciucchi, Sara; Barone, Domenico; Gavelli, Giampaolo; Dubini, Alessandra; Oboldi, Devil; Matteuci, Federica (2012). "Primary Hyperparathyroidism: Imaging to Pathology
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