Look mainly for malignancy.
Reactive mesothelium, with typical features. Wright's stain. Reactive mesothelium may be due to infection, trauma or cancer.
Compare to normal mesothelium. Wright's stain
When finding adenocarcinoma in pleural fluid in a female, and there is no other specimen, preferably perform immunostaining including PAX-8 and WT-1 to confirm a Müllerian tract origin. Also consider p53 to distinguish low-grade (wild-type staining) from high grade (aberrant staining) serous ovarian carcinoma.
Comment: Immunohistochemistry was performed, and showed tumor cells positive for PAX-8 and WT-1, and negative (null phenotype) for p53. These findings are consistent with a tumor of Müllerian (serous) origin.
- Image by Mikael Häggström. MD.
Reference for findings and causes: . Reactive Mesothelial Cells. LabCE.
- Image by Mikael Häggström
- . Mesothelial cytopathology. Libre Pathology. Retrieved on 2022-10-18.
- Shidham VB, Layfield LJ (2021). "Introduction to the second edition of 'Diagnostic Cytopathology of Serous Fluids' as CytoJournal Monograph (CMAS) in Open Access. ". Cytojournal 18: 30. doi:10.25259/CMAS_02_01_2021. PMID 35126608.