Peritoneal fluid
Author:
Mikael Häggström, M.D. [note 1]
Contents
Evaluation
Look mainly for malignancy.
Reactive mesothelium, with typical features. Wright's stain. Reactive mesothelium may be due to infection, trauma or cancer.[1]
Compare to normal mesothelium[2]. Wright's stain
When finding adenocarcinoma in pleural fluid in a female, and there is no other specimen, preferably perform immunostaining including PAX-8 and WT-1 to confirm a Müllerian tract origin. Also consider p53 to distinguish low-grade (wild-type staining) from high grade (aberrant staining) serous ovarian carcinoma.
Reporting
Example report:
Peritoneal fluid:
Comment: Immunohistochemistry was performed, and showed tumor cells positive for PAX-8 and WT-1, and negative (null phenotype) for p53. These findings are consistent with a tumor of Müllerian (serous) origin. |
Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ Image by Mikael Häggström. MD.
Reference for findings and causes: . Reactive Mesothelial Cells. LabCE. - ↑ Image by Mikael Häggström
- . Mesothelial cytopathology. Libre Pathology. Retrieved on 2022-10-18.
- Shidham VB, Layfield LJ (2021). "Introduction to the second edition of 'Diagnostic Cytopathology of Serous Fluids' as CytoJournal Monograph (CMAS) in Open Access. ". Cytojournal 18: 30. doi: . PMID 35126608.
Image sources