Difference between revisions of "Pigmented macrophages of the lung"

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| Siderophage (black arrow), and interstitium with edema, hemosiderin deposition (black arrow) and collagenous thickening.
 
| Siderophage (black arrow), and interstitium with edema, hemosiderin deposition (black arrow) and collagenous thickening.
 
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[[File:Histopathology of smoker's macrophages with anthracotic stippling.jpg|thumb|Histopathology of smoker's macrophages with anthracotic stippling, indicating the presence of both respiratory bronchiolitis and [[anthracosis]].]]
 
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Revision as of 10:46, 21 May 2021

Author: Mikael Häggström [note 1]
When seeing pigmented macrophages of the lung, categorize as follows:

Disease Macrophages Pigment appearance (HE stain) Associated medical history Image Image comment
Anthracosis Black-brown granules
  • Age and urban dwelling.[1]
  • Coal workers[2]
 Histopathology of anthracotic macrophage in lung, annotated.jpg Black arrow shows interstitial anthracotic pigment. Nearby macrophages (white arrow) can be presumed to contain anthracotic pigment. Reporting is optional in mild cases in the elderly.
Respiratory bronchiolitis "Smoker's macrophages" Yellow to light brown and finely granular[3] Tobacco smoking Histopathology of a smoker's macrophage.jpg Smoker's macrophages (arrow); mild interstitial lymphocytic infiltrate and mild fibrosis (arrowhead)[4]
Chronic pulmonary congestion Siderophages Brown-golden and refractile.[5]
  • Heart failure
  • Pulmonary hemorrhage
 Histopathology of siderophage in chronic pulmonary congestion.jpg Siderophage (black arrow), and interstitium with edema, hemosiderin deposition (black arrow) and collagenous thickening.
Histopathology of smoker's macrophages with anthracotic stippling, indicating the presence of both respiratory bronchiolitis and anthracosis.

Notes

  1. ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.

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References

  1. ↑ Cotran; Kumar, Collins (1999). Robbins Pathologic Basis of Disease . Philadelphia: W.B Saunders Company. ISBN 978-0-7216-7335-6. 
  2. ↑ Morgan WK (November 1978). "Industrial bronchitis ". Br J Ind Med 35 (4): 285–91. PMID 367424. 
  3. ↑ William Perry, M.D., M.P.H., Kristine Konopka, M.D.. Lung - Other interstitial pneumonitis / fibrosis - Respiratory bronchiolitis. Topic Completed: 1 July 2020. Minor changes: 1 July 2020.
  4. ↑ Sousa, Célia; Rodrigues, Márcio; Carvalho, André; Viamonte, Bárbara; Cunha, Rui; Guimarães, Susana; de Moura, Conceição Souto; Morais, António; et al. (2019). "Diffuse smoking-related lung diseases: insights from a radiologic-pathologic correlation ". Insights into Imaging 10 (1). doi:10.1186/s13244-019-0765-z. ISSN 1869-4101. 
    - This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/)
  5. ↑ Zander, Dani (2018). Pulmonary pathology . Philadelphia, PA: Elsevier. ISBN 978-0-323-39308-9. OCLC 968711140.  - VII Acute Lung Injury with Siderophages

Image sources


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