Difference between revisions of "Pigmented macrophages of the lung"
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{|class=wikitable | {|class=wikitable | ||
| − | ! Disease !! | + | ! Disease !! Macrophage name !! Macrophage pigment appearance (HE stain) !! Usual macrophage location || Associated medical history !! Image !! Image comment |
|- | |- | ||
! Anthracosis | ! Anthracosis | ||
| − | | || Black-brown granules | + | | || Black-brown granules || Interstitium (perivascular) |
| | | | ||
*Age and urban dwelling.<ref name="robspath">{{cite book | title=Robbins Pathologic Basis of Disease| last=Cotran|author2=Kumar, Collins| publisher=W.B Saunders Company| location=Philadelphia| isbn=978-0-7216-7335-6| year=1999}}</ref> | *Age and urban dwelling.<ref name="robspath">{{cite book | title=Robbins Pathologic Basis of Disease| last=Cotran|author2=Kumar, Collins| publisher=W.B Saunders Company| location=Philadelphia| isbn=978-0-7216-7335-6| year=1999}}</ref> | ||
| Line 18: | Line 18: | ||
! Respiratory bronchiolitis | ! Respiratory bronchiolitis | ||
| "Smoker's macrophages" | | "Smoker's macrophages" | ||
| − | | Yellow to light brown and finely granular<ref>{{cite web|url=https://www.pathologyoutlines.com/topic/lungnontumorrespbronchiolitis.html|title=Lung - Other interstitial pneumonitis / fibrosis - Respiratory bronchiolitis|author=William Perry, M.D., M.P.H., Kristine Konopka, M.D.}} Topic Completed: 1 July 2020. Minor changes: 1 July 2020.</ref> || Tobacco smoking | + | | Yellow to light brown and finely granular<ref>{{cite web|url=https://www.pathologyoutlines.com/topic/lungnontumorrespbronchiolitis.html|title=Lung - Other interstitial pneumonitis / fibrosis - Respiratory bronchiolitis|author=William Perry, M.D., M.P.H., Kristine Konopka, M.D.}} Topic Completed: 1 July 2020. Minor changes: 1 July 2020.</ref> || Airways (especially respiratory bronchioles) || Tobacco smoking |
| [[File:Histopathology of a smoker's macrophage.jpg|200px]] | | [[File:Histopathology of a smoker's macrophage.jpg|200px]] | ||
| Smoker's macrophages (arrow); mild interstitial lymphocytic infiltrate and mild fibrosis (arrowhead)<ref>{{cite journal|last1=Sousa|first1=Célia|last2=Rodrigues|first2=Márcio|last3=Carvalho|first3=André|last4=Viamonte|first4=Bárbara|last5=Cunha|first5=Rui|last6=Guimarães|first6=Susana|last7=de Moura|first7=Conceição Souto|last8=Morais|first8=António|last9=Pereira|first9=José Miguel|title=Diffuse smoking-related lung diseases: insights from a radiologic-pathologic correlation|journal=Insights into Imaging|volume=10|issue=1|year=2019|issn=1869-4101|doi=10.1186/s13244-019-0765-z}}<br>- This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/)</ref> | | Smoker's macrophages (arrow); mild interstitial lymphocytic infiltrate and mild fibrosis (arrowhead)<ref>{{cite journal|last1=Sousa|first1=Célia|last2=Rodrigues|first2=Márcio|last3=Carvalho|first3=André|last4=Viamonte|first4=Bárbara|last5=Cunha|first5=Rui|last6=Guimarães|first6=Susana|last7=de Moura|first7=Conceição Souto|last8=Morais|first8=António|last9=Pereira|first9=José Miguel|title=Diffuse smoking-related lung diseases: insights from a radiologic-pathologic correlation|journal=Insights into Imaging|volume=10|issue=1|year=2019|issn=1869-4101|doi=10.1186/s13244-019-0765-z}}<br>- This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/)</ref> | ||
| Line 24: | Line 24: | ||
! '''Chronic pulmonary congestion''' | ! '''Chronic pulmonary congestion''' | ||
| Siderophages || Brown-golden and refractile.<ref>{{cite book | last=Zander | first=Dani | title=Pulmonary pathology | publisher=Elsevier | publication-place=Philadelphia, PA | year=2018 | isbn=978-0-323-39308-9 | oclc=968711140}} - VII Acute Lung Injury with Siderophages</ref> | | Siderophages || Brown-golden and refractile.<ref>{{cite book | last=Zander | first=Dani | title=Pulmonary pathology | publisher=Elsevier | publication-place=Philadelphia, PA | year=2018 | isbn=978-0-323-39308-9 | oclc=968711140}} - VII Acute Lung Injury with Siderophages</ref> | ||
| + | | [[Pulmonary alveolus|Alveoli]]<ref>{{cite book|author1= Guido Majno|author2=Isabelle Joris|title=Cells, Tissues, and Disease : Principles of General Pathology|url=https://books.google.com/books?id=8yAf6U7njlcC&pg=PA620|accessdate=19 March 2013|date=12 August 2004|publisher=Oxford University Press|isbn=978-0-19-974892-1|page=620}}</ref> | ||
| | | | ||
*Heart failure | *Heart failure | ||
Revision as of 11:08, 21 May 2021
Author:
Mikael Häggström [note 1]
When seeing pigmented macrophages of the lung, categorize as follows:
| Disease | Macrophage name | Macrophage pigment appearance (HE stain) | Usual macrophage location | Associated medical history | Image | Image comment |
|---|---|---|---|---|---|---|
| Anthracosis | Black-brown granules | Interstitium (perivascular) | 
|
Black arrow shows interstitial anthracotic pigment. Nearby macrophages (white arrow) can be presumed to contain anthracotic pigment. Reporting is optional in mild cases in the elderly. | ||
| Respiratory bronchiolitis | "Smoker's macrophages" | Yellow to light brown and finely granular[3] | Airways (especially respiratory bronchioles) | Tobacco smoking | 
|
Smoker's macrophages (arrow); mild interstitial lymphocytic infiltrate and mild fibrosis (arrowhead)[4] |
| Chronic pulmonary congestion | Siderophages | Brown-golden and refractile.[5] | Alveoli[6] |
|
|
Siderophage (black arrow), and interstitium with edema, hemosiderin deposition (black arrow) and collagenous thickening. |
Histopathology of smoker's macrophages with anthracotic stippling, indicating the presence of both respiratory bronchiolitis and anthracosis.
Contents
Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ Cotran; Kumar, Collins (1999). Robbins Pathologic Basis of Disease . Philadelphia: W.B Saunders Company. ISBN 978-0-7216-7335-6.
- ↑ Morgan WK (November 1978). "Industrial bronchitis ". Br J Ind Med 35 (4): 285–91. PMID 367424.
- ↑ William Perry, M.D., M.P.H., Kristine Konopka, M.D.. Lung - Other interstitial pneumonitis / fibrosis - Respiratory bronchiolitis. Topic Completed: 1 July 2020. Minor changes: 1 July 2020.
- ↑ Sousa, Célia; Rodrigues, Márcio; Carvalho, André; Viamonte, Bárbara; Cunha, Rui; Guimarães, Susana; de Moura, Conceição Souto; Morais, António; et al. (2019). "Diffuse smoking-related lung diseases: insights from a radiologic-pathologic correlation
". Insights into Imaging 10 (1). doi:. ISSN 1869-4101.
- This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/) - ↑ Zander, Dani (2018). Pulmonary pathology . Philadelphia, PA: Elsevier. ISBN 978-0-323-39308-9. OCLC 968711140. - VII Acute Lung Injury with Siderophages
- ↑ Guido Majno; Isabelle Joris (12 August 2004). Cells, Tissues, and Disease : Principles of General Pathology . Oxford University Press. p. 620. ISBN 978-0-19-974892-1. Retrieved on 19 March 2013.
Image sources
