Difference between revisions of "Pigmented macrophages of the lung"
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*Age and urban dwelling.<ref name="robspath">{{cite book | title=Robbins Pathologic Basis of Disease| last=Cotran|author2=Kumar, Collins| publisher=W.B Saunders Company| location=Philadelphia| isbn=978-0-7216-7335-6| year=1999}}</ref> | *Age and urban dwelling.<ref name="robspath">{{cite book | title=Robbins Pathologic Basis of Disease| last=Cotran|author2=Kumar, Collins| publisher=W.B Saunders Company| location=Philadelphia| isbn=978-0-7216-7335-6| year=1999}}</ref> | ||
*Coal workers<ref>{{cite journal |author=Morgan WK |title=Industrial bronchitis |journal=Br J Ind Med |volume=35 |issue=4 |pages=285–91 |date=November 1978 |pmid=367424 |pmc=1008445 }}</ref> | *Coal workers<ref>{{cite journal |author=Morgan WK |title=Industrial bronchitis |journal=Br J Ind Med |volume=35 |issue=4 |pages=285–91 |date=November 1978 |pmid=367424 |pmc=1008445 }}</ref> | ||
| − | | [[File:Histopathology of anthracotic macrophage in lung, annotated.jpg| | + | | [[File:Histopathology of anthracotic macrophage in lung, annotated.jpg|180px]] |
| Black arrow shows interstitial anthracotic pigment. Nearby macrophages (white arrow) can be presumed to contain anthracotic pigment. Reporting is optional in mild cases in the elderly. | | Black arrow shows interstitial anthracotic pigment. Nearby macrophages (white arrow) can be presumed to contain anthracotic pigment. Reporting is optional in mild cases in the elderly. | ||
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| "Smoker's macrophages" | | "Smoker's macrophages" | ||
| Yellow to light brown and finely granular<ref>{{cite web|url=https://www.pathologyoutlines.com/topic/lungnontumorrespbronchiolitis.html|title=Lung - Other interstitial pneumonitis / fibrosis - Respiratory bronchiolitis|author=William Perry, M.D., M.P.H., Kristine Konopka, M.D.}} Topic Completed: 1 July 2020. Minor changes: 1 July 2020.</ref> || Airways (especially respiratory bronchioles) || Tobacco smoking | | Yellow to light brown and finely granular<ref>{{cite web|url=https://www.pathologyoutlines.com/topic/lungnontumorrespbronchiolitis.html|title=Lung - Other interstitial pneumonitis / fibrosis - Respiratory bronchiolitis|author=William Perry, M.D., M.P.H., Kristine Konopka, M.D.}} Topic Completed: 1 July 2020. Minor changes: 1 July 2020.</ref> || Airways (especially respiratory bronchioles) || Tobacco smoking | ||
| − | | [[File:Histopathology of a smoker's macrophage.jpg| | + | | [[File:Histopathology of a smoker's macrophage.jpg|180px]] |
| Smoker's macrophage in center. | | Smoker's macrophage in center. | ||
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*Heart failure | *Heart failure | ||
*Pulmonary hemorrhage | *Pulmonary hemorrhage | ||
| − | | [[File:Histopathology of siderophage in chronic pulmonary congestion.jpg| | + | | [[File:Histopathology of siderophage in chronic pulmonary congestion.jpg|180px]] |
| − | | Siderophage (black arrow), and interstitium with edema, hemosiderin deposition (black arrow) and collagenous thickening. | + | | Siderophage (black arrow), and interstitium with edema, hemosiderin deposition (black arrow) and collagenous thickening, indicating heart failure. |
|} | |} | ||
[[File:Histopathology of smoker's macrophages with anthracotic stippling.jpg|thumb|Histopathology of smoker's macrophages with anthracotic stippling, indicating the presence of both respiratory bronchiolitis and [[anthracosis]].]] | [[File:Histopathology of smoker's macrophages with anthracotic stippling.jpg|thumb|Histopathology of smoker's macrophages with anthracotic stippling, indicating the presence of both respiratory bronchiolitis and [[anthracosis]].]] | ||
{{Bottom}} | {{Bottom}} | ||
Revision as of 11:13, 21 May 2021
Author:
Mikael Häggström [note 1]
When seeing pigmented macrophages of the lung, categorize as follows:
| Disease | Macrophage name | Macrophage pigment appearance (HE stain) | Usual macrophage location | Associated medical history | Image | Image comment |
|---|---|---|---|---|---|---|
| Anthracosis | Black-brown granules | Interstitium (perivascular) | 
|
Black arrow shows interstitial anthracotic pigment. Nearby macrophages (white arrow) can be presumed to contain anthracotic pigment. Reporting is optional in mild cases in the elderly. | ||
| Respiratory bronchiolitis | "Smoker's macrophages" | Yellow to light brown and finely granular[3] | Airways (especially respiratory bronchioles) | Tobacco smoking | 
|
Smoker's macrophage in center. |
| Chronic pulmonary congestion | Siderophages | Brown-golden and refractile.[4] | Alveoli[5] |
|
|
Siderophage (black arrow), and interstitium with edema, hemosiderin deposition (black arrow) and collagenous thickening, indicating heart failure. |
Histopathology of smoker's macrophages with anthracotic stippling, indicating the presence of both respiratory bronchiolitis and anthracosis.
Contents
Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ Cotran; Kumar, Collins (1999). Robbins Pathologic Basis of Disease . Philadelphia: W.B Saunders Company. ISBN 978-0-7216-7335-6.
- ↑ Morgan WK (November 1978). "Industrial bronchitis ". Br J Ind Med 35 (4): 285–91. PMID 367424.
- ↑ William Perry, M.D., M.P.H., Kristine Konopka, M.D.. Lung - Other interstitial pneumonitis / fibrosis - Respiratory bronchiolitis. Topic Completed: 1 July 2020. Minor changes: 1 July 2020.
- ↑ Zander, Dani (2018). Pulmonary pathology . Philadelphia, PA: Elsevier. ISBN 978-0-323-39308-9. OCLC 968711140. - VII Acute Lung Injury with Siderophages
- ↑ Guido Majno; Isabelle Joris (12 August 2004). Cells, Tissues, and Disease : Principles of General Pathology . Oxford University Press. p. 620. ISBN 978-0-19-974892-1. Retrieved on 19 March 2013.
Image sources
