Difference between revisions of "Pilomatricoma"
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[[File:Histopathology of pilomatricoma, high magnification, annotated.jpg|thumb|230px|Histopathology of pilomatricoma, high magnification, H&E stain, showing the characteristic components.{{MH}}]] | [[File:Histopathology of pilomatricoma, high magnification, annotated.jpg|thumb|230px|Histopathology of pilomatricoma, high magnification, H&E stain, showing the characteristic components.{{MH}}]] | ||
| − | [[File:Histopathology of pilomatricoma, low magnification.jpg|thumb|230px|Low magnifications, also revealing foreign body giant cells and calcifications, which are also common within pilomatricomas.{{MH}}<ref>{{cite book |editor1-first=David E. |editor1-last=Elder |editor2-first=Bernett L. |editor2-last=Johnson |editor3-first=Rosalie |editor3-last=Elenitsas |year=2005 |title=Lever's Histopathology of the Skin |publisher=Lippincott Williams & Wilkins |isbn=978-0-7817-3742-5 }}</ref>. | + | [[File:Histopathology of pilomatricoma, low magnification.jpg|thumb|230px|Low magnifications, also revealing foreign body giant cells and calcifications, which are also common within pilomatricomas.{{MH}}<ref>{{cite book |editor1-first=David E. |editor1-last=Elder |editor2-first=Bernett L. |editor2-last=Johnson |editor3-first=Rosalie |editor3-last=Elenitsas |year=2005 |title=Lever's Histopathology of the Skin |publisher=Lippincott Williams & Wilkins |isbn=978-0-7817-3742-5 }}</ref>.]] |
Pilomatricomas generally present as '''[[skin cyst]]s'''. | Pilomatricomas generally present as '''[[skin cyst]]s'''. | ||
Revision as of 11:19, 25 September 2021
Author:
Mikael Häggström [note 1]
Pilomatricomas generally present as skin cysts.
Contents
Microscopic evaluation
The characteristic components of a pilomatricoma include a stroma of fibrovascular connective tissue surrounding irregularly shaped, lobulated islands containing basaloid cells (being darkly stained, round or elongated, with indistinct cell borders and minimal cytoplasm, with nuclei being round to ovoid, deeply basophilic and generally prominent nucleoli), which abruptly or gradually transitions into ghost cells (having abundant, pale, eosinophilic cytoplasm, well defined cell borders and a central clear area, but only only faint traces of nuclear material), which in turn may transition into keratinaceous to amorphous necrosis.[2]
Differential diagnoses
Mainly:
Epidermoid cyst, having the following typical findings:[3]
- Stratified squamous epithelium with a granular layer
- Cyst wall does not contain eccrine glands, sebaceous glands or hair follicles
- Abundant keratin flakes in cyst lumen
- Often giant cell granuloma in ruptured cysts, similar to foreign body granuloma.
Trichilemmal cyst, containing, from external (top) to internal (bottom):[4]
- Fibrous capsule
- Small, cuboidal, dark-staining basal epithelial cells in a palisade arrangement, with no distinct intercellular bridging
- Swollen pale keratinocytes, which increase in height closer to the interior
- Solid eosinophilic-staining keratin
There is no granular cell layer (in contrast to an epidermoid cyst).
Further information: Skin cyst
Microscopic report
Preferably brief:
| Right cheek skin, excision: Pilomatricoma |
Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ Elder, David E.; Johnson, Bernett L.; Elenitsas, Rosalie, eds (2005). Lever's Histopathology of the Skin . Lippincott Williams & Wilkins. ISBN 978-0-7817-3742-5.
- ↑ Punnya V Angadi (2009-06-01). Skin: Pilomatricoma. Atlas of Genetics and Cytogenetics in Oncology and Haematology.
- ↑ V. Claire Vaughan, M.D., Joshua Wisell, M.D.. Skin nonmelanocytic tumor - Cysts - Epidermal (epidermoid) type. pathology Outlines. Topic Completed: 9 May 2019. Revised: 13 December 2019
- ↑ Anne Elizabeth Laumann. Which histologic findings are characteristic of trichilemmal cyst (pilar cyst)?. Medscape. Updated: Jun 11, 2020,
Image sources
- ↑ 1.0 1.1 Image(s) by: Mikael Häggström, M.D. Public Domain
- Author info
- Reusing images
