Difference between revisions of "Pituitary"
Jump to navigation
Jump to search
(+Report) |
(→Microscopic evaluation: +Normal) |
||
Line 5: | Line 5: | ||
==Microscopic evaluation== | ==Microscopic evaluation== | ||
− | *Look for '''cellular expansions''' | + | *Look for '''cellular expansions''', which in the anterior pituitary confers a loss of normal cellular heterogeneity. |
*If present, distinguish it as '''hyperplasia or neoplasia'''. If uncertain, by using reticulin immunohistochemistry, hyperplasia will show a preserved reticulin meshwork, whereas pituitary adenomas have disruption of it.<ref name="Al-BrahimAsa2006">{{cite journal|last1=Al-Brahim|first1=N Y Y|last2=Asa|first2=S L|title=My approach to pathology of the pituitary gland|journal=Journal of Clinical Pathology|volume=59|issue=12|year=2006|pages=1245–1253|issn=0021-9746|doi=10.1136/jcp.2005.031187}}</ref> | *If present, distinguish it as '''hyperplasia or neoplasia'''. If uncertain, by using reticulin immunohistochemistry, hyperplasia will show a preserved reticulin meshwork, whereas pituitary adenomas have disruption of it.<ref name="Al-BrahimAsa2006">{{cite journal|last1=Al-Brahim|first1=N Y Y|last2=Asa|first2=S L|title=My approach to pathology of the pituitary gland|journal=Journal of Clinical Pathology|volume=59|issue=12|year=2006|pages=1245–1253|issn=0021-9746|doi=10.1136/jcp.2005.031187}}</ref> | ||
:*For '''adenomas''', unless otherwise indicated by the medical history, will generally by definition be of the silent type. Basophilic or acidophilic staining may give a clue about the subtype, but immunohistochemistry is generally required. | :*For '''adenomas''', unless otherwise indicated by the medical history, will generally by definition be of the silent type. Basophilic or acidophilic staining may give a clue about the subtype, but immunohistochemistry is generally required. | ||
<gallery> | <gallery> | ||
+ | File:Histology of pars distalis of the anterior pituitary with chromophobes, basophils, and acidophils, annotated.jpg|'''Normal''' cellular heterogeneity of the anterior pituitary. Nuclear pleomorphism, like the large nucleus of the chromophobe, is a normal finding in this location. | ||
File:Pie chart of incidences of silent pituitary adenomas.png|Incidences of silent pituitary adenomas.<ref>{{cite journal|last1=Drummond|first1=Juliana|last2=Roncaroli|first2=Federico|last3=Grossman|first3=Ashley B|last4=Korbonits|first4=Márta|title=Clinical and Pathological Aspects of Silent Pituitary Adenomas|journal=The Journal of Clinical Endocrinology & Metabolism|volume=104|issue=7|year=2019|pages=2473–2489|issn=0021-972X|doi=10.1210/jc.2018-00688}}<br>- "This article has been published under the terms of the Creative Commons Attribution License (CC BY; https://creativecommons.org/licenses/by/4.0/)"</ref> | File:Pie chart of incidences of silent pituitary adenomas.png|Incidences of silent pituitary adenomas.<ref>{{cite journal|last1=Drummond|first1=Juliana|last2=Roncaroli|first2=Federico|last3=Grossman|first3=Ashley B|last4=Korbonits|first4=Márta|title=Clinical and Pathological Aspects of Silent Pituitary Adenomas|journal=The Journal of Clinical Endocrinology & Metabolism|volume=104|issue=7|year=2019|pages=2473–2489|issn=0021-972X|doi=10.1210/jc.2018-00688}}<br>- "This article has been published under the terms of the Creative Commons Attribution License (CC BY; https://creativecommons.org/licenses/by/4.0/)"</ref> | ||
− | File:Histopathology of eosinophilic silent gonadotroph pituitary adenoma.jpg|A silent gonadotroph pituitary adenoma which is in this case is eosinophilic (contrary to normal, basophilic, gonadotroph cells).<ref>{{cite journal|last1=Gaballa|first1=Salem|last2=Lindsay|first2=Jane|last3=AlJaf|first3=Avan|last4=Hlaing|first4=Kyaw M|last5=Patel|first5=Kashyap|title=Acute Unilateral Oculomotor Nerve Palsy as the Initial Presenting Sign of Nonfunctioning Apoplectic Gonadotroph Adenoma|journal=Cureus|year=2020|issn=2168-8184|doi=10.7759/cureus.8819}}<br>- "This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0"</ref> | + | File:Histopathology of eosinophilic silent gonadotroph pituitary adenoma.jpg|A silent gonadotroph pituitary '''adenoma''' which is in this case is eosinophilic (contrary to normal, basophilic, gonadotroph cells).<ref>{{cite journal|last1=Gaballa|first1=Salem|last2=Lindsay|first2=Jane|last3=AlJaf|first3=Avan|last4=Hlaing|first4=Kyaw M|last5=Patel|first5=Kashyap|title=Acute Unilateral Oculomotor Nerve Palsy as the Initial Presenting Sign of Nonfunctioning Apoplectic Gonadotroph Adenoma|journal=Cureus|year=2020|issn=2168-8184|doi=10.7759/cureus.8819}}<br>- "This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0"</ref> |
</gallery> | </gallery> | ||
Revision as of 09:37, 11 February 2021
Author:
Mikael Häggström [note 1]
Contents
Microscopic evaluation
- Look for cellular expansions, which in the anterior pituitary confers a loss of normal cellular heterogeneity.
- If present, distinguish it as hyperplasia or neoplasia. If uncertain, by using reticulin immunohistochemistry, hyperplasia will show a preserved reticulin meshwork, whereas pituitary adenomas have disruption of it.[1]
- For adenomas, unless otherwise indicated by the medical history, will generally by definition be of the silent type. Basophilic or acidophilic staining may give a clue about the subtype, but immunohistochemistry is generally required.
Incidences of silent pituitary adenomas.[2]
A silent gonadotroph pituitary adenoma which is in this case is eosinophilic (contrary to normal, basophilic, gonadotroph cells).[3]
Microscopy report
In normal autopsy:
Adenohypophysis and neurohypophysis with no focal changes. |
Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
Main page
References
- ↑ Al-Brahim, N Y Y; Asa, S L (2006). "My approach to pathology of the pituitary gland ". Journal of Clinical Pathology 59 (12): 1245–1253. doi: . ISSN 0021-9746.
- ↑ Drummond, Juliana; Roncaroli, Federico; Grossman, Ashley B; Korbonits, Márta (2019). "Clinical and Pathological Aspects of Silent Pituitary Adenomas
". The Journal of Clinical Endocrinology & Metabolism 104 (7): 2473–2489. doi: . ISSN 0021-972X.
- "This article has been published under the terms of the Creative Commons Attribution License (CC BY; https://creativecommons.org/licenses/by/4.0/)" - ↑ Gaballa, Salem; Lindsay, Jane; AlJaf, Avan; Hlaing, Kyaw M; Patel, Kashyap (2020). "Acute Unilateral Oculomotor Nerve Palsy as the Initial Presenting Sign of Nonfunctioning Apoplectic Gonadotroph Adenoma
". Cureus. doi: . ISSN 2168-8184.
- "This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0"
Image sources