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Author: Mikael Häggström [note 1]


Microscopic evaluation

  • Look for cellular expansions, which in the anterior pituitary confers a loss of normal cellular heterogeneity.
  • If present, distinguish it as hyperplasia or neoplasia. If uncertain, by using reticulin immunohistochemistry, hyperplasia will show a preserved reticulin meshwork, whereas pituitary adenomas have disruption of it.[1]
  • For adenomas, unless otherwise indicated by the medical history, will generally by definition be of the silent type. Basophilic or acidophilic staining may give a clue about the subtype, but immunohistochemistry is generally required.

Microscopy report

In normal autopsy:

Adenohypophysis and neurohypophysis with no focal changes.


  1. For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.

Main page


  1. Al-Brahim, N Y Y; Asa, S L (2006). "My approach to pathology of the pituitary gland ". Journal of Clinical Pathology 59 (12): 1245–1253. doi:10.1136/jcp.2005.031187. ISSN 0021-9746. 
  2. Drummond, Juliana; Roncaroli, Federico; Grossman, Ashley B; Korbonits, Márta (2019). "Clinical and Pathological Aspects of Silent Pituitary Adenomas ". The Journal of Clinical Endocrinology & Metabolism 104 (7): 2473–2489. doi:10.1210/jc.2018-00688. ISSN 0021-972X. 
    - "This article has been published under the terms of the Creative Commons Attribution License (CC BY; https://creativecommons.org/licenses/by/4.0/)"
  3. Gaballa, Salem; Lindsay, Jane; AlJaf, Avan; Hlaing, Kyaw M; Patel, Kashyap (2020). "Acute Unilateral Oculomotor Nerve Palsy as the Initial Presenting Sign of Nonfunctioning Apoplectic Gonadotroph Adenoma ". Cureus. doi:10.7759/cureus.8819. ISSN 2168-8184. 
    - "This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0"

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