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- Look for cellular expansions, which in the anterior pituitary confers a loss of normal cellular heterogeneity.
- If present, distinguish it as hyperplasia or neoplasia. If uncertain, by using reticulin immunohistochemistry, hyperplasia will show a preserved reticulin meshwork, whereas pituitary adenomas have disruption of it.
- For adenomas, unless otherwise indicated by the medical history, will generally by definition be of the silent type. Basophilic or acidophilic staining may give a clue about the subtype, but immunohistochemistry is generally required.
Incidences of silent pituitary adenomas.
A silent gonadotroph pituitary adenoma which is in this case is eosinophilic (contrary to normal, basophilic, gonadotroph cells).
In normal autopsy:
|Adenohypophysis and neurohypophysis with no focal changes.|
- Al-Brahim, N Y Y; Asa, S L (2006). "My approach to pathology of the pituitary gland ". Journal of Clinical Pathology 59 (12): 1245–1253. doi:10.1136/jcp.2005.031187. ISSN 0021-9746.
- Drummond, Juliana; Roncaroli, Federico; Grossman, Ashley B; Korbonits, Márta (2019). "Clinical and Pathological Aspects of Silent Pituitary Adenomas
". The Journal of Clinical Endocrinology & Metabolism 104 (7): 2473–2489. doi:10.1210/jc.2018-00688. ISSN 0021-972X.
- "This article has been published under the terms of the Creative Commons Attribution License (CC BY; https://creativecommons.org/licenses/by/4.0/)"
- Gaballa, Salem; Lindsay, Jane; AlJaf, Avan; Hlaing, Kyaw M; Patel, Kashyap (2020). "Acute Unilateral Oculomotor Nerve Palsy as the Initial Presenting Sign of Nonfunctioning Apoplectic Gonadotroph Adenoma
". Cureus. doi:10.7759/cureus.8819. ISSN 2168-8184.
- "This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0"