Reactive lymph node
Author:
Mikael Häggström [note 1]
A reactive lymph node (or reactive lymphadenopathy) is a lymph node pattern that is usually secondary to inflammation.
Contents
Gross examination
Grossing as per lymph nodes in general.
An unspecific gross sign of a reactive lymph node is enlargement. Further information: Lymph node
Microscopic examination
Microscopic signs of reactive lymphadenopathy:
Follicular hyperplasia. However, follicular lymphoma should be excluded. Further information: Follicular hyperplasia
- Paracortical hyperplasia with expansion of paracortical areas by a mixed infiltrate, often having a mottled appearance, and it usually has a concomitant reactive follicular hyperplasia.[1] A T-cell lymphoma should be suspected if there is obliteration or marked diminution of the B-cell cortical region, or highly irregular or hyperchromatic nuclei.[1]
- Unspecific hyperplasia: An unspecific pattern of lymph node enlargement, without atypical cells, in the lymphatic drainage direction from an inflamed area, may be diagnosed as "benign reactive lymph node".
Reporting
Reactive lymphadenopathy may be reported as:
((A. Labeled - ___. The specimen is received in formalin and consists of))(( one (1))) reactive lymph node((, negative for metastatic carcinoma)). (Representative sections are submitted for microscopic examination in __ cassettes.) |
Notes
- ↑ For a full list of contributors, see article history. Creators of images are attributed at the image description pages, seen by clicking on the images. See Patholines:Authorship for details.
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References
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